Q8YZ37 (HEM61_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coproporphyrinogen-III oxidase, aerobic 1
Short name=Coprogen oxidase 1
Short name=Coproporphyrinogenase 1
EC=1.3.3.3

Gene names

Name:	hemF1
Ordered Locus Names:	all0650

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333
Catalytic activity	Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333
Subunit structure	Homodimer By similarity. HAMAP MF_00333
Subcellular location	Cytoplasm By similarity HAMAP MF_00333.
Sequence similarities	Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Coproporphyrinogen-III oxidase, aerobic 1 HAMAP MF_00333		PRO_0000109880
Regions
	Region	38 – 47	10	Important for dimerization By similarity
	Region	98 – 100	3	Substrate binding By similarity
	Region	251 – 286	36	Important for dimerization By similarity
	Region	269 – 274	6	Substrate binding By similarity
Sites
	Active site	96	1	Proton donor By similarity
	Binding site	82	1	Substrate By similarity
	Site	160	1	Important for dimerization By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YZ37 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: CF8C5E2A5B5C7E8E	FASTA	317	36,514
	10 20 30 40 50 60 MKQLQDEITQ ALTKLDGGSE FHEDSWERPE GGGGRSRVLR DGAIFEQAGV NFSEVWGSHL 70 80 90 100 110 120 PPSILAQRPE AEGHGFYATG TSLVLHPRNP YVPTVHLNYR YFEAGPVWWF GGGADLTPYY 130 140 150 160 170 180 PFAEDAAHFH QTLKLACDEH HPEYYPVFKR WCDEYFYLKH RDETRGVGGL FFDYQDGQGV 190 200 210 220 230 240 LYRGPNPKGE AANYSNQVGE PASRDWEDLF SFIQGSGKAF LPAYVPIVER RHGMEYGDRQ 250 260 270 280 290 300 RNFQLYRRGR YVEFNLVYDR GTIFGLQTNG RTESILMSLP PLVRWEYGYQ PEPNSPEAEL 310 YDTFLKPQDW SNWTANQ

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB72608.1.
PIR	AI1887.
RefSeq	NP_484694.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YZ37.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YZ37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1104246.
GenomeReviews	Gene locus all0650 in contig BA000019_GR.
KEGG	ana:all0650.
NMPDR	fig|103690.1.peg.961.
PATRIC	22771110. VBINosSp37423_1043.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0408.
HOGENOM	HBG631180.
OMA	YLFEEDC.
PhylomeDB	Q8YZ37.
ProtClustDB	PRK05330.
Enzyme and pathway databases
BioCyc	NSP103690:ALL0650-MONOMER.
Family and domain databases
HAMAP	MF_00333. Coprogen_oxidas. [Tree]
InterPro	IPR001260. Coprogen_oxidase_aer. IPR018375. Coprogen_oxidase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KO	K00228.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 2 hits. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
SUPFAM	SSF102886. Coprogen_oxidas. 1 hit.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM61_NOSS1

Accession

Primary (citable) accession number: Q8YZ37

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program