Reviewed, UniProtKB/Swiss-Prot Q8YYK4 (PTH_ANASP)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	all0844

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187680

Sequences

	Sequence		Length	Mass (Da)
	Q8YYK4-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: CBADE623FB94DB35	FASTA	203	21,981
	10 20 30 40 50 60 MIPQLIVGLG NPEPKYDQTR HNIGFAAVDA LARAWNISLA ENRKFQGQYG EGTAPGGVKI 70 80 90 100 110 120 RLLKPLTYMN RSGQAIQAVT SWYKLSGESV LVIYDDLDLP LGKTRLRLSG SAGGHNGMKS 130 140 150 160 170 180 AIAHLSTQNF PRLRIGIGKP KNAVNGDNSE TVSHVLGKFS ATETQLMSLV LQFVVECVEL 190 200 SLKQGVEKAM NRCNSCTVEA PKS

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB72801.1.
PIR	AB1912.
RefSeq	NP_484887.1.
3D structure databases
SMR	Q8YYK4. Positions 4-198.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YYK4.
Genome annotation databases
GeneID	1104439.
GenomeReviews	Gene locus all0844 in contig BA000019_GR.
KEGG	ana:all0844.
NMPDR	fig|103690.1.peg.1154.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HBG610927.
OMA	IKFKTGG.
PhylomeDB	Q8YYK4.
Enzyme and pathway databases
BioCyc	NSP103690:ALL0844-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_ANASP

Accession

Primary (citable) accession number: Q8YYK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)