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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase 1 (pfkA1), ATP-dependent 6-phosphofructokinase 2 (pfkA2)
  4. Fructose-bisphosphate aldolase (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei322 – 3221Proton donorUniRule annotation
Active sitei351 – 3511UniRule annotation
Active sitei455 – 4551UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:alr1050
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Glucose-6-phosphate isomerasePRO_0000180582Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.alr1050.

Structurei

3D structure databases

ProteinModelPortaliQ8YY05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000131425.
KOiK01810.
OMAiRQVGHYW.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 2 hits.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YY05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKALWQRY QEWLYFHEGL GLYLDVSRMR FDDAFVKSLL PKFDKAFADM
60 70 80 90 100
AELEKGAIAN PDENRMVGHY WLRNPDLAPT PEIAQEIVQT LEQIEAFAEK
110 120 130 140 150
IQTGAIHPPK ANRFTDIISI GIGGSALGPQ FVAEALAPEF PPLKIHFIDN
160 170 180 190 200
TDPAGIDRIL THLRNHLAST LVLVISKSGG TPEPRNGMIE VKKAYAGQNL
210 220 230 240 250
DFAQYAVAIT STGSNLDKVA QSEGWLATFP MYDWVGGRTS EMSSVGLVPA
260 270 280 290 300
ALQGIDVRAM LEGAKEMDDA TRVPEVKNNP AALLALSWYY SGNGKGEKDM
310 320 330 340 350
VVLPYKDSLL LFSRYLQQLV MESLGKEKDL DGNTVYQGIA VYGNKGSTDQ
360 370 380 390 400
HAYVQQLREG VPNFFATLIE VLEDRHGASP EIDPGVTSGD YLSGFLLGTR
410 420 430 440 450
QALYENQRDS ITVTIPQVNA RTVGALVALY ERTVGLYASL VNINAYHQPG
460 470 480 490 500
VEAGKKAAAV ILDLQTKVVG LLQKEKTALS LEQIAEKIGA ADQVEAIYKI
510 520
LRHLQANQRG VVFQGNLGQP SSLKISLS
Length:528
Mass (Da):57,819
Last modified:March 27, 2002 - v1
Checksum:i694C42CE28DEEBED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73007.1.
PIRiAG1937.
RefSeqiNP_485093.1. NC_003272.1.
WP_010995224.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73007; BAB73007; BAB73007.
KEGGiana:alr1050.
PATRICi22772004. VBINosSp37423_1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73007.1.
PIRiAG1937.
RefSeqiNP_485093.1. NC_003272.1.
WP_010995224.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YY05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73007; BAB73007; BAB73007.
KEGGiana:alr1050.
PATRICi22772004. VBINosSp37423_1486.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000131425.
KOiK01810.
OMAiRQVGHYW.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 2 hits.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiG6PI_NOSS1
AccessioniPrimary (citable) accession number: Q8YY05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.