Q8YXZ4 (MSRA1_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 1
Short name=Protein-methionine-S-oxide reductase 1
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1
Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Ordered Locus Names:	all1062

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Peptide methionine sulfoxide reductase MsrA 1 HAMAP MF_01401		PRO_0000138527
Sites
	Active site	21	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YXZ4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 49AB056BCDCCE657	FASTA	163	18,524
	10 20 30 40 50 60 MELKIGSTEA PMEKATFGAG CFWGVEAAFR KVKGVVSTSV GYMGGHFPNP CYLDVLSRIT 70 80 90 100 110 120 GHAEVVQIEY DPQLVSYEDL LAVFWDIHDP TTLNRQGPDK GEQYRSVIFF HNEQQAEAAQ 130 140 150 160 QSKAKVQVSG RFELDIVTEI KHKSEYYLAT EEHQQYFEKQ AKR

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73019.1.
PIR	AC1939.
RefSeq	NP_485105.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YXZ4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YXZ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1104656.
GenomeReviews	Gene locus all1062 in contig BA000019_GR.
KEGG	ana:all1062.
NMPDR	fig|103690.1.peg.1372.
PATRIC	22772032. VBINosSp37423_1500.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	EDKIVTE.
PhylomeDB	Q8YXZ4.
ProtClustDB	PRK13014.
Enzyme and pathway databases
BioCyc	NSP103690:ALL1062-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_NOSS1

Accession

Primary (citable) accession number: Q8YXZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program