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Protein

Anthranilate phosphoribosyltransferase 2

Gene

trpD2

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase 1 (trpD1), Anthranilate phosphoribosyltransferase 2 (trpD2)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei103Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei111PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi115Magnesium 1UniRule annotation1
Binding sitei134Anthranilate 1UniRule annotation1
Binding sitei143PhosphoribosylpyrophosphateUniRule annotation1
Binding sitei189Anthranilate 2UniRule annotation1
Metal bindingi248Magnesium 2UniRule annotation1
Metal bindingi249Magnesium 1UniRule annotation1
Metal bindingi249Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase 2UniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpD2UniRule annotation
Ordered Locus Names:alr1153
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001544201 – 362Anthranilate phosphoribosyltransferase 2Add BLAST362

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi103690.alr1153.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 23Combined sources8
Helixi30 – 41Combined sources12
Helixi47 – 60Combined sources14
Helixi64 – 75Combined sources12
Beta strandi94 – 96Combined sources3
Beta strandi99 – 103Combined sources5
Helixi114 – 124Combined sources11
Beta strandi129 – 134Combined sources6
Helixi143 – 149Combined sources7
Helixi158 – 167Combined sources10
Beta strandi169 – 175Combined sources7
Helixi180 – 185Combined sources6
Helixi186 – 192Combined sources7
Helixi197 – 201Combined sources5
Helixi202 – 204Combined sources3
Beta strandi211 – 216Combined sources6
Helixi220 – 222Combined sources3
Helixi223 – 232Combined sources10
Beta strandi236 – 243Combined sources8
Turni244 – 246Combined sources3
Beta strandi247 – 249Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi256 – 262Combined sources7
Beta strandi265 – 271Combined sources7
Helixi273 – 276Combined sources4
Helixi283 – 286Combined sources4
Helixi291 – 302Combined sources12
Helixi308 – 324Combined sources17
Helixi333 – 346Combined sources14
Helixi348 – 361Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VQUX-ray1.85A/B1-362[»]
ProteinModelPortaliQ8YXQ9.
SMRiQ8YXQ9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8YXQ9.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 107Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni113 – 116Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni131 – 139Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiVKMAREF.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YXQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSPTSTQE SSTSWYLLLQ QLIDGESLSR SQAAELMQGW LSEAVPPELS
60 70 80 90 100
GAILTALNFK GVSADELTGM AEVLQSQSKM GTGENYSQLP ITNSPFSIID
110 120 130 140 150
TCGTGGDGSS TFNISTAVAF VAAAYGVPVA KHGNRSASSL TGSADVLEAL
160 170 180 190 200
GVNLGASPEK VQAALQEVGI TFLFAPGWHP ALKAVATLRR TLRIRTVFNL
210 220 230 240 250
LGPLVNPLRP TGQVVGLFTP KLLTTVAQAL DNLGKQKAIV LHGRERLDEA
260 270 280 290 300
GLGDLTDLAV LSDGELQLTT INPQEVGVTP APIGALRGGD VQENAEILKA
310 320 330 340 350
VLQGKGTQAQ QDAVALNAAL ALQVAGAVPL LDHAQGVSVA KEILQTGTAW
360
AKLAQLVYFL GN
Length:362
Mass (Da):37,598
Last modified:March 1, 2002 - v1
Checksum:iC392D1446391AC13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73110.1.
PIRiAF1950.
RefSeqiWP_010995326.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73110; BAB73110; BAB73110.
KEGGiana:alr1153.
PATRICi22772232. VBINosSp37423_1600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73110.1.
PIRiAF1950.
RefSeqiWP_010995326.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VQUX-ray1.85A/B1-362[»]
ProteinModelPortaliQ8YXQ9.
SMRiQ8YXQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73110; BAB73110; BAB73110.
KEGGiana:alr1153.
PATRICi22772232. VBINosSp37423_1600.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiVKMAREF.
OrthoDBiPOG091H01QX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Miscellaneous databases

EvolutionaryTraceiQ8YXQ9.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD2_NOSS1
AccessioniPrimary (citable) accession number: Q8YXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.