Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anthranilate phosphoribosyltransferase 2

Gene

trpD2

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase 1 (trpD1), Anthranilate phosphoribosyltransferase 2 (trpD2)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei103 – 1031Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei111 – 1111PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi115 – 1151Magnesium 1UniRule annotation
Binding sitei134 – 1341Anthranilate 1UniRule annotation
Binding sitei143 – 1431PhosphoribosylpyrophosphateUniRule annotation
Binding sitei189 – 1891Anthranilate 2UniRule annotation
Metal bindingi248 – 2481Magnesium 2UniRule annotation
Metal bindingi249 – 2491Magnesium 1UniRule annotation
Metal bindingi249 – 2491Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase 2UniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpD2UniRule annotation
Ordered Locus Names:alr1153
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Anthranilate phosphoribosyltransferase 2PRO_0000154420Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi103690.alr1153.

Structurei

Secondary structure

1
362
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 238Combined sources
Helixi30 – 4112Combined sources
Helixi47 – 6014Combined sources
Helixi64 – 7512Combined sources
Beta strandi94 – 963Combined sources
Beta strandi99 – 1035Combined sources
Helixi114 – 12411Combined sources
Beta strandi129 – 1346Combined sources
Helixi143 – 1497Combined sources
Helixi158 – 16710Combined sources
Beta strandi169 – 1757Combined sources
Helixi180 – 1856Combined sources
Helixi186 – 1927Combined sources
Helixi197 – 2015Combined sources
Helixi202 – 2043Combined sources
Beta strandi211 – 2166Combined sources
Helixi220 – 2223Combined sources
Helixi223 – 23210Combined sources
Beta strandi236 – 2438Combined sources
Turni244 – 2463Combined sources
Beta strandi247 – 2493Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi256 – 2627Combined sources
Beta strandi265 – 2717Combined sources
Helixi273 – 2764Combined sources
Helixi283 – 2864Combined sources
Helixi291 – 30212Combined sources
Helixi308 – 32417Combined sources
Helixi333 – 34614Combined sources
Helixi348 – 36114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VQUX-ray1.85A/B1-362[»]
ProteinModelPortaliQ8YXQ9.
SMRiQ8YXQ9. Positions 13-362.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8YXQ9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni113 – 1164Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni131 – 1399Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiVKMAREF.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YXQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSPTSTQE SSTSWYLLLQ QLIDGESLSR SQAAELMQGW LSEAVPPELS
60 70 80 90 100
GAILTALNFK GVSADELTGM AEVLQSQSKM GTGENYSQLP ITNSPFSIID
110 120 130 140 150
TCGTGGDGSS TFNISTAVAF VAAAYGVPVA KHGNRSASSL TGSADVLEAL
160 170 180 190 200
GVNLGASPEK VQAALQEVGI TFLFAPGWHP ALKAVATLRR TLRIRTVFNL
210 220 230 240 250
LGPLVNPLRP TGQVVGLFTP KLLTTVAQAL DNLGKQKAIV LHGRERLDEA
260 270 280 290 300
GLGDLTDLAV LSDGELQLTT INPQEVGVTP APIGALRGGD VQENAEILKA
310 320 330 340 350
VLQGKGTQAQ QDAVALNAAL ALQVAGAVPL LDHAQGVSVA KEILQTGTAW
360
AKLAQLVYFL GN
Length:362
Mass (Da):37,598
Last modified:March 1, 2002 - v1
Checksum:iC392D1446391AC13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73110.1.
PIRiAF1950.
RefSeqiWP_010995326.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73110; BAB73110; BAB73110.
KEGGiana:alr1153.
PATRICi22772232. VBINosSp37423_1600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73110.1.
PIRiAF1950.
RefSeqiWP_010995326.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VQUX-ray1.85A/B1-362[»]
ProteinModelPortaliQ8YXQ9.
SMRiQ8YXQ9. Positions 13-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73110; BAB73110; BAB73110.
KEGGiana:alr1153.
PATRICi22772232. VBINosSp37423_1600.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiVKMAREF.
OrthoDBiPOG091H01QX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Miscellaneous databases

EvolutionaryTraceiQ8YXQ9.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD2_NOSS1
AccessioniPrimary (citable) accession number: Q8YXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.