Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8YXQ7 (CARA_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain
EC=6.3.5.5
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain
Gene names
Name:carA
Ordered Locus Names:alr1155
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP MF_01209

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity.

Sequence similarities

Belongs to the CarA family.

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Carbamoyl-phosphate synthase small chain HAMAP MF_01209
PRO_0000112244

Regions

Domain196 – 382187Glutamine amidotransferase type-1
Region1 – 192192CPSase HAMAP MF_01209

Sites

Active site2721Nucleophile By similarity
Active site3551 By similarity
Active site3571 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YXQ7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 062A038D8F4B706E

FASTA38842,257
        10         20         30         40         50         60 
MPLSDAMPAL LVLADGTAYR GWSFGATGTT IGEVVFNTGM TGYQEVLTDP SYRGQIVVFT 

        70         80         90        100        110        120 
YPELGNTGVN PEDEESARPQ VRGAIARNIC HKPSNWRSTQ SLPDYLKQHH IPGIFGIDTR 

       130        140        150        160        170        180 
ALTRKIRMYG AMNGGISTEI LDEAELLEQV QAAPNMAGLN LVREVTTSTV YEWSDPTTAV 

       190        200        210        220        230        240 
WEFNPDGTVK NGESLTVVAL DFGVKRNILR RLASYGCRVI VVPADTSPEE ILKYNPDGIF 

       250        260        270        280        290        300 
LSNGPGDPSA VTEGITTAKA LLESEKPIFG ICMGHQILGH ALGAETFKLK FGHRGLNQPA 

       310        320        330        340        350        360 
GLTQRVEITS QNHSFAIDPD SLPEAVVEIS HLNLNDRTVA GLRHKSLPIF SVQYHPEASP 

       370        380 
GPHDADYLFA QFVHQMRTTK QATTAEVS

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000019 Genomic DNA. Translation: BAB73112.1.
PIRAH1950.
RefSeqNP_485198.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YXQ7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8YXQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1104749.
GenomeReviewsGene locus alr1155 in contig BA000019_GR.
KEGGana:alr1155.
NMPDRfig|103690.1.peg.1465.
PATRIC22772238. VBINosSp37423_1603.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0505.
HOGENOMHBG286341.
OMAFTYPELG.
PhylomeDBQ8YXQ7.
ProtClustDBPRK12564.

Enzyme and pathway databases

BioCycNSP103690:ALR1155-MONOMER.

Family and domain databases

HAMAPMF_01209. CPSase_S_chain.
[Tree]
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
Gene3DG3DSA:3.50.30.20. G3DSA:3.50.30.20. 1 hit.
KOK01956.
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCARA_NOSS1
AccessionPrimary (citable) accession number: Q8YXQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents