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Q8YXJ9 (UPPP_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:all1214
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151081

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane296 – 31621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8YXJ9 [UniParc].

Last modified March 5, 2002. Version 1.
Checksum: 536A5E90A96F66EF

FASTA32033,952
        10         20         30         40         50         60 
MSIFKRQWFV LISAVSAALS VVLFPLEVFS ASPNSGGGGV QQMNILQAIV LGFVQGMTEF 

        70         80         90        100        110        120 
LPISSTAHLK VVPVALGWGD PGVAFTAIIQ LGSIAAVLWY FWGDLTRIIK GATRAIALKD 

       130        140        150        160        170        180 
YADYDLRLSL GIVLGTIPIV FFGLLIKTFI PDYDSSPIRS LGAIAVASIV MSLLLGVGEK 

       190        200        210        220        230        240 
LGKRERDFEH LTMQDGLLMG LAQALTLIPG VSRSGSTLTS GLFMGLQRET AARFSFLLGI 

       250        260        270        280        290        300 
PAITLAGLVE LKDLLAEGIA DGAALPLIMG VISAAIFSYL AIAGLLSFLK TQSTWVFIWY 

       310        320 
RLVFGVAILG AISAGILQNS 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB73171.1.
PIRAC1958.
RefSeqNP_485257.1. NC_003272.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.all1214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB73171; BAB73171; BAB73171.
GeneID1104809.
KEGGana:all1214.
PATRIC22772362. VBINosSp37423_1665.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAEYLFHER.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_NOSS1
AccessionPrimary (citable) accession number: Q8YXJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families