Reviewed, UniProtKB/Swiss-Prot Q8YXG9 (AROK_ANASP)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	alr1244

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Shikimate kinase HAMAP MF_00109		PRO_0000192365
Regions
	Nucleotide binding	17 – 22	6	ATP By similarity
Sites
	Metal binding	21	1	Magnesium By similarity
	Binding site	39	1	Substrate By similarity
	Binding site	63	1	Substrate By similarity
	Binding site	85	1	Substrate; via amide nitrogen By similarity
	Binding site	122	1	ATP By similarity
	Binding site	141	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YXG9-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 2E89FBAC8D32FE03	FASTA	181	19,816
	10 20 30 40 50 60 MSSLLQGVNL YLIGMMGAGK TTVGHLLAKE LGYGFLDTDN VIAQATKKSI NEIFAEAGEA 70 80 90 100 110 120 GFRQIESDVL AQVCSYTKLT VATGGGIVLR RENWSYLHHG LILWLDVPVD ILYARLAADT 130 140 150 160 170 180 TRPLLQDDDP KGKLRSLLEQ RTPLYSQADL RICVNAEETP EQIANKVMQA IPSVLKQTAS N

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB73201.1.
PIR	AI1961.
RefSeq	NP_485287.1.
3D structure databases
HSSP	HSSP built from PDB template 1SHK based on UniProtKB P10880.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YXG9.
Genome annotation databases
GeneID	1104839.
GenomeReviews	Gene locus alr1244 in contig BA000019_GR.
KEGG	ana:alr1244.
NMPDR	fig|103690.1.peg.1554.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YXG9.
OMA	HANVFFV.
Enzyme and pathway databases
BioCyc	NSP103690:ALR1244-MON.
Family and domain databases
HAMAP	MF_00109. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_ANASP

Accession

Primary (citable) accession number: Q8YXG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)