Q8YXG8 (ARGB_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	alr1245

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112574
Regions
	Region	73 – 74	2	Substrate binding By similarity
Sites
	Binding site	95	1	Substrate By similarity
	Binding site	188	1	Substrate By similarity
	Site	38	1	Transition state stabilizer By similarity
	Site	251	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YXG8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 94114AC26BA35438	FASTA	297	31,560
	10 20 30 40 50 60 MMVNDIEYIR QAEATRVQVL SEALPYIQQF AGRTVVVKYG GAAMKDSHLK DQVIRDIVFL 70 80 90 100 110 120 SCVGLRPILV HGGGPEINSW LDKLGIEAQF KNGLRVTDAP TMDVVEMVLV GRVNKEIVSL 130 140 150 160 170 180 INQAGGLAVG LCGKDGNLIT ARPQGQEGIG FVGEVSNVNI KILETLASNG YIPVVSSVAA 190 200 210 220 230 240 DDSGQAYNIN ADTVAGEIAA ALGAEKLILL TDTRGILKDY QDPGTLIPKV DIREARELIN 250 260 270 280 290 SGVVSGGMIP KVTCCVRSLA QGVRAAHIID GRIPHALLLE IFTDVGIGTM ILGSQYS

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73202.1.
PIR	AB1962.
RefSeq	NP_485288.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YXG8.
SMR	Q8YXG8. Positions 14-296.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YXG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1104840.
GenomeReviews	Gene locus alr1245 in contig BA000019_GR.
KEGG	ana:alr1245.
NMPDR	fig|103690.1.peg.1555.
PATRIC	22772436. VBINosSp37423_1702.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q8YXG8.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	NSP103690:ALR1245-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_NOSS1

Accession

Primary (citable) accession number: Q8YXG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program