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Q8YX96

- PANE_NOSS1

UniProt

Q8YX96 - PANE_NOSS1

Protein

Putative 2-dehydropantoate 2-reductase

Gene

all1319

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (21 Feb 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei105 – 1051NADP; via amide nitrogenBy similarity
    Binding sitei105 – 1051SubstrateBy similarity
    Active sitei192 – 1921Proton donorBy similarity
    Binding sitei196 – 1961SubstrateBy similarity
    Binding sitei200 – 2001SubstrateBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Binding sitei274 – 2741NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:all1319
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Putative 2-dehydropantoate 2-reductasePRO_0000157309Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.all1319.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YX96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiYLLVATK.
    OrthoDBiEOG693GMJ.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YX96-1 [UniParc]FASTAAdd to Basket

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    MNERKYAILG TGALGGYYGA KLQKAGSDVH FLLKSDYEKV NQDGLLVESK    50
    DGDFTLPQVN AYNDVAKMPK CDVVVVALKT TQNHLLPKLL PPIVKNDGIV 100
    LVLQNGLGVE EEIAEILPQV HIIGGLCFLC SNKVGAGYIH HLDYGQITLG 150
    EYAHGYSNMG ITDRMQQISH DFQTAGISIE LLEDLLLGRW KKLVWNIPYN 200
    GLSVVLNART DELMADTYTR TLVEQLMYEV KAGAKSMGRN IPDSFIQTML 250
    DYTVKMKPYR TSMKIDYDEC RPLEVEAIVG NPLHKAQEVG VNLPQINCLY 300
    HQLKFLDGRN RTGQLTVDS 319
    Length:319
    Mass (Da):35,574
    Last modified:February 21, 2002 - v1
    Checksum:i7A53C6138C39A483
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB73276.1.
    PIRiAD1971.
    RefSeqiNP_485362.1. NC_003272.1.
    WP_010995491.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB73276; BAB73276; BAB73276.
    GeneIDi1104914.
    KEGGiana:all1319.
    PATRICi22772598. VBINosSp37423_1783.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB73276.1 .
    PIRi AD1971.
    RefSeqi NP_485362.1. NC_003272.1.
    WP_010995491.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YX96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.all1319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB73276 ; BAB73276 ; BAB73276 .
    GeneIDi 1104914.
    KEGGi ana:all1319.
    PATRICi 22772598. VBINosSp37423_1783.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi YLLVATK.
    OrthoDBi EOG693GMJ.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiPANE_NOSS1
    AccessioniPrimary (citable) accession number: Q8YX96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: February 21, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3