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Protein

Putative 2-dehydropantoate 2-reductase

Gene

all1319

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (all1319)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105NADP; via amide nitrogenBy similarity1
Binding sitei105SubstrateBy similarity1
Active sitei192Proton donorBy similarity1
Binding sitei196SubstrateBy similarity1
Binding sitei200SubstrateBy similarity1
Binding sitei262SubstrateBy similarity1
Binding sitei274NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:all1319
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573091 – 319Putative 2-dehydropantoate 2-reductaseAdd BLAST319

Proteomic databases

PRIDEiQ8YX96

Interactioni

Protein-protein interaction databases

STRINGi103690.all1319

Structurei

3D structure databases

ProteinModelPortaliQ8YX96
SMRiQ8YX96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiENOG41084M5 Bacteria
COG1893 LUCA
HOGENOMiHOG000050222
KOiK00077
OMAiVLGGQCV
OrthoDBiPOG091H01MS

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YX96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNERKYAILG TGALGGYYGA KLQKAGSDVH FLLKSDYEKV NQDGLLVESK
60 70 80 90 100
DGDFTLPQVN AYNDVAKMPK CDVVVVALKT TQNHLLPKLL PPIVKNDGIV
110 120 130 140 150
LVLQNGLGVE EEIAEILPQV HIIGGLCFLC SNKVGAGYIH HLDYGQITLG
160 170 180 190 200
EYAHGYSNMG ITDRMQQISH DFQTAGISIE LLEDLLLGRW KKLVWNIPYN
210 220 230 240 250
GLSVVLNART DELMADTYTR TLVEQLMYEV KAGAKSMGRN IPDSFIQTML
260 270 280 290 300
DYTVKMKPYR TSMKIDYDEC RPLEVEAIVG NPLHKAQEVG VNLPQINCLY
310
HQLKFLDGRN RTGQLTVDS
Length:319
Mass (Da):35,574
Last modified:February 21, 2002 - v1
Checksum:i7A53C6138C39A483
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA Translation: BAB73276.1
PIRiAD1971
RefSeqiWP_010995491.1, NC_003272.1

Genome annotation databases

EnsemblBacteriaiBAB73276; BAB73276; BAB73276
KEGGiana:all1319

Similar proteinsi

Entry informationi

Entry nameiPANE_NOSS1
AccessioniPrimary (citable) accession number: Q8YX96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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