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Protein

Putative 2-dehydropantoate 2-reductase

Gene

all1319

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADP; via amide nitrogenBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Active sitei192 – 1921Proton donorBy similarity
Binding sitei196 – 1961SubstrateBy similarity
Binding sitei200 – 2001SubstrateBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Binding sitei274 – 2741NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:all1319
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Putative 2-dehydropantoate 2-reductasePRO_0000157309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all1319.

Structurei

3D structure databases

ProteinModelPortaliQ8YX96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiKLVWNIP.
OrthoDBiEOG693GMJ.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YX96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNERKYAILG TGALGGYYGA KLQKAGSDVH FLLKSDYEKV NQDGLLVESK
60 70 80 90 100
DGDFTLPQVN AYNDVAKMPK CDVVVVALKT TQNHLLPKLL PPIVKNDGIV
110 120 130 140 150
LVLQNGLGVE EEIAEILPQV HIIGGLCFLC SNKVGAGYIH HLDYGQITLG
160 170 180 190 200
EYAHGYSNMG ITDRMQQISH DFQTAGISIE LLEDLLLGRW KKLVWNIPYN
210 220 230 240 250
GLSVVLNART DELMADTYTR TLVEQLMYEV KAGAKSMGRN IPDSFIQTML
260 270 280 290 300
DYTVKMKPYR TSMKIDYDEC RPLEVEAIVG NPLHKAQEVG VNLPQINCLY
310
HQLKFLDGRN RTGQLTVDS
Length:319
Mass (Da):35,574
Last modified:February 21, 2002 - v1
Checksum:i7A53C6138C39A483
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73276.1.
PIRiAD1971.
RefSeqiNP_485362.1. NC_003272.1.
WP_010995491.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73276; BAB73276; BAB73276.
GeneIDi1104914.
KEGGiana:all1319.
PATRICi22772598. VBINosSp37423_1783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73276.1.
PIRiAD1971.
RefSeqiNP_485362.1. NC_003272.1.
WP_010995491.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YX96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.all1319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73276; BAB73276; BAB73276.
GeneIDi1104914.
KEGGiana:all1319.
PATRICi22772598. VBINosSp37423_1783.

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiKLVWNIP.
OrthoDBiEOG693GMJ.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiPANE_NOSS1
AccessioniPrimary (citable) accession number: Q8YX96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.