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Q8YX96

- PANE_NOSS1

UniProt

Q8YX96 - PANE_NOSS1

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Protein

Putative 2-dehydropantoate 2-reductase

Gene
all1319
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADP; via amide nitrogen By similarity
Binding sitei105 – 1051Substrate By similarity
Active sitei192 – 1921Proton donor By similarity
Binding sitei196 – 1961Substrate By similarity
Binding sitei200 – 2001Substrate By similarity
Binding sitei262 – 2621Substrate By similarity
Binding sitei274 – 2741NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:all1319
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Putative 2-dehydropantoate 2-reductasePRO_0000157309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all1319.

Structurei

3D structure databases

ProteinModelPortaliQ8YX96.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiYLLVATK.
OrthoDBiEOG693GMJ.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YX96-1 [UniParc]FASTAAdd to Basket

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MNERKYAILG TGALGGYYGA KLQKAGSDVH FLLKSDYEKV NQDGLLVESK    50
DGDFTLPQVN AYNDVAKMPK CDVVVVALKT TQNHLLPKLL PPIVKNDGIV 100
LVLQNGLGVE EEIAEILPQV HIIGGLCFLC SNKVGAGYIH HLDYGQITLG 150
EYAHGYSNMG ITDRMQQISH DFQTAGISIE LLEDLLLGRW KKLVWNIPYN 200
GLSVVLNART DELMADTYTR TLVEQLMYEV KAGAKSMGRN IPDSFIQTML 250
DYTVKMKPYR TSMKIDYDEC RPLEVEAIVG NPLHKAQEVG VNLPQINCLY 300
HQLKFLDGRN RTGQLTVDS 319
Length:319
Mass (Da):35,574
Last modified:February 21, 2002 - v1
Checksum:i7A53C6138C39A483
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB73276.1.
PIRiAD1971.
RefSeqiNP_485362.1. NC_003272.1.
WP_010995491.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73276; BAB73276; BAB73276.
GeneIDi1104914.
KEGGiana:all1319.
PATRICi22772598. VBINosSp37423_1783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB73276.1 .
PIRi AD1971.
RefSeqi NP_485362.1. NC_003272.1.
WP_010995491.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YX96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all1319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB73276 ; BAB73276 ; BAB73276 .
GeneIDi 1104914.
KEGGi ana:all1319.
PATRICi 22772598. VBINosSp37423_1783.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi YLLVATK.
OrthoDBi EOG693GMJ.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiPANE_NOSS1
AccessioniPrimary (citable) accession number: Q8YX96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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