Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Binding sitei192NADUniRule annotation1
Binding sitei244NADUniRule annotation1
Binding sitei279NADUniRule annotation1
Binding sitei347NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 160NADUniRule annotation3
Nucleotide bindingi221 – 226NADUniRule annotation6
Nucleotide bindingi300 – 302NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:alr1414
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

Q8YX05:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169401 – 425AdenosylhomocysteinaseAdd BLAST425

Interactioni

Protein-protein interaction databases

STRINGi103690.alr1414.

Structurei

3D structure databases

ProteinModelPortaliQ8YX05.
SMRiQ8YX05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YX05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATSPRLKH EVKDLALAPL GRQRIEWAGR EMPVLRQIRD RFAQEKPFAG
60 70 80 90 100
LRLVACAHIT TETAHLAIAL KAGGADAVLI ASNPLSTQDD VAASLVLDHE
110 120 130 140 150
IPVFAQKGED NATYNRHVQI ALDHRPNIII DDGSDVVATL VQERQHQIAD
160 170 180 190 200
LIGTTEETTT GIVRLRAMFK DGVLTFPAVN VNDADTKHFF DNRYGTGQST
210 220 230 240 250
LDGIIRATNI LLAGKNVVVV GYGWCGKGTA LRARGMGANV IVTEIDPIKA
260 270 280 290 300
IEAVMDGFRV LPMAEAAPQG DIFITVTGNK HVVRGEHFDV MKDGAIVCNS
310 320 330 340 350
GHFDLELDLK YLAANAKEIK EVRPFTEEYK LTNGKSVVVL GQGRLINLAA
360 370 380 390 400
AEGHPSAVMD MSFANQALAC EYLVKNKGKL APGLHSIPVE VDQEIARLKL
410 420
QAMGIYIDSL TPEQIEYINS WTSGT
Length:425
Mass (Da):46,172
Last modified:March 1, 2002 - v1
Checksum:i38B232B91E0E46E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73371.1.
PIRiAC1983.
RefSeqiWP_010995586.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73371; BAB73371; BAB73371.
KEGGiana:alr1414.

Similar proteinsi

Entry informationi

Entry nameiSAHH_NOSS1
AccessioniPrimary (citable) accession number: Q8YX05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families