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Q8YWL4

- HISX2_NOSS1

UniProt

Q8YWL4 - HISX2_NOSS1

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Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADBy similarity
Binding sitei192 – 1921NADBy similarity
Binding sitei215 – 2151NADBy similarity
Binding sitei238 – 2381SubstrateBy similarity
Metal bindingi260 – 2601ZincBy similarity
Binding sitei260 – 2601SubstrateBy similarity
Metal bindingi263 – 2631ZincBy similarity
Binding sitei263 – 2631SubstrateBy similarity
Active sitei328 – 3281Proton acceptorBy similarity
Active sitei329 – 3291Proton acceptorBy similarity
Binding sitei329 – 3291SubstrateBy similarity
Metal bindingi362 – 3621ZincBy similarity
Binding sitei362 – 3621SubstrateBy similarity
Binding sitei416 – 4161SubstrateBy similarity
Metal bindingi421 – 4211ZincBy similarity
Binding sitei421 – 4211SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:all1591
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenase 2PRO_0000135716Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all1591.

Structurei

3D structure databases

ProteinModelPortaliQ8YWL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiFQEITRE.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YWL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRIITQQAD VKAELQRICD RTHDEQVLHK EATVREVLQA VKRQGDKAVL
60 70 80 90 100
HYTDEFDNQI LKAEELRVTG SELDAAYQQV SQELLEAIQL ASRQIEAFHR
110 120 130 140 150
QRVPKSWVHF GDDDIVLGKR YTPIDRAGLY VPGGRAAYVS TVLMNAIPAR
160 170 180 190 200
VAGVPRIVIA TPPGAQKAIN PAVLVAAQEV GVQEIYRVGG AQAIAALAYG
210 220 230 240 250
TETIPKVDVI TGPGNIYVTL AKKLVYGNVG IDSLAGPSEV LIIADEGANP
260 270 280 290 300
VHVATDMLAQ AEHDPMAAAI LFTTDPALAK NVQVAVERQL VDHPRRIDTE
310 320 330 340 350
KAIAHYGLIV LVESLDAAAE LSNEFAPEHL ELEVKDPWAV LPNIRHAGAI
360 370 380 390 400
FLGYSTPEAV GDYLAGPNHT LPTSGAARYA SALSVETFLK HSSIIQYSQT
410 420 430
ALNKVAGAID ALATAEGLPS HADSVKRRIQ QDE
Length:433
Mass (Da):46,738
Last modified:March 1, 2002 - v1
Checksum:i1617B2369C86E624
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB77957.1.
PIRiAI2004.
RefSeqiNP_485631.1. NC_003272.1.
WP_010995760.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB77957; BAB77957; BAB77957.
GeneIDi1105183.
KEGGiana:all1591.
PATRICi22773210. VBINosSp37423_2085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB77957.1 .
PIRi AI2004.
RefSeqi NP_485631.1. NC_003272.1.
WP_010995760.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YWL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all1591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB77957 ; BAB77957 ; BAB77957 .
GeneIDi 1105183.
KEGGi ana:all1591.
PATRICi 22773210. VBINosSp37423_2085.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi FQEITRE.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiHISX2_NOSS1
AccessioniPrimary (citable) accession number: Q8YWL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3