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Q8YWL4

- HISX2_NOSS1

UniProt

Q8YWL4 - HISX2_NOSS1

Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADBy similarity
    Binding sitei192 – 1921NADBy similarity
    Binding sitei215 – 2151NADBy similarity
    Binding sitei238 – 2381SubstrateBy similarity
    Metal bindingi260 – 2601ZincBy similarity
    Binding sitei260 – 2601SubstrateBy similarity
    Metal bindingi263 – 2631ZincBy similarity
    Binding sitei263 – 2631SubstrateBy similarity
    Active sitei328 – 3281Proton acceptorBy similarity
    Active sitei329 – 3291Proton acceptorBy similarity
    Binding sitei329 – 3291SubstrateBy similarity
    Metal bindingi362 – 3621ZincBy similarity
    Binding sitei362 – 3621SubstrateBy similarity
    Binding sitei416 – 4161SubstrateBy similarity
    Metal bindingi421 – 4211ZincBy similarity
    Binding sitei421 – 4211SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 2 (EC:1.1.1.23)
    Short name:
    HDH 2
    Gene namesi
    Name:hisD2
    Ordered Locus Names:all1591
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Histidinol dehydrogenase 2PRO_0000135716Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.all1591.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YWL4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiFQEITRE.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YWL4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRIITQQAD VKAELQRICD RTHDEQVLHK EATVREVLQA VKRQGDKAVL    50
    HYTDEFDNQI LKAEELRVTG SELDAAYQQV SQELLEAIQL ASRQIEAFHR 100
    QRVPKSWVHF GDDDIVLGKR YTPIDRAGLY VPGGRAAYVS TVLMNAIPAR 150
    VAGVPRIVIA TPPGAQKAIN PAVLVAAQEV GVQEIYRVGG AQAIAALAYG 200
    TETIPKVDVI TGPGNIYVTL AKKLVYGNVG IDSLAGPSEV LIIADEGANP 250
    VHVATDMLAQ AEHDPMAAAI LFTTDPALAK NVQVAVERQL VDHPRRIDTE 300
    KAIAHYGLIV LVESLDAAAE LSNEFAPEHL ELEVKDPWAV LPNIRHAGAI 350
    FLGYSTPEAV GDYLAGPNHT LPTSGAARYA SALSVETFLK HSSIIQYSQT 400
    ALNKVAGAID ALATAEGLPS HADSVKRRIQ QDE 433
    Length:433
    Mass (Da):46,738
    Last modified:March 1, 2002 - v1
    Checksum:i1617B2369C86E624
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB77957.1.
    PIRiAI2004.
    RefSeqiNP_485631.1. NC_003272.1.
    WP_010995760.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB77957; BAB77957; BAB77957.
    GeneIDi1105183.
    KEGGiana:all1591.
    PATRICi22773210. VBINosSp37423_2085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB77957.1 .
    PIRi AI2004.
    RefSeqi NP_485631.1. NC_003272.1.
    WP_010995760.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YWL4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.all1591.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB77957 ; BAB77957 ; BAB77957 .
    GeneIDi 1105183.
    KEGGi ana:all1591.
    PATRICi 22773210. VBINosSp37423_2085.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi FQEITRE.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiHISX2_NOSS1
    AccessioniPrimary (citable) accession number: Q8YWL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3