Reviewed, UniProtKB/Swiss-Prot Q8YWL4 (HISX2_ANASP)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 2
      Short name=HDH 2
    EC=1.1.1.23

Gene names

Name:	hisD2
Ordered Locus Names:	all1591

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Histidinol dehydrogenase 2		PRO_0000135716
Sites
	Active site	328	1	Proton acceptor By similarity
	Active site	329	1	Proton acceptor By similarity
	Metal binding	260	1	Zinc By similarity
	Metal binding	263	1	Zinc By similarity
	Metal binding	362	1	Zinc By similarity
	Metal binding	421	1	Zinc By similarity
	Binding site	130	1	NAD By similarity
	Binding site	192	1	NAD By similarity
	Binding site	215	1	NAD By similarity
	Binding site	238	1	Substrate By similarity
	Binding site	260	1	Substrate By similarity
	Binding site	263	1	Substrate By similarity
	Binding site	329	1	Substrate By similarity
	Binding site	362	1	Substrate By similarity
	Binding site	416	1	Substrate By similarity
	Binding site	421	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YWL4-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 1617B2369C86E624	FASTA	433	46,738
	10 20 30 40 50 60 MLRIITQQAD VKAELQRICD RTHDEQVLHK EATVREVLQA VKRQGDKAVL HYTDEFDNQI 70 80 90 100 110 120 LKAEELRVTG SELDAAYQQV SQELLEAIQL ASRQIEAFHR QRVPKSWVHF GDDDIVLGKR 130 140 150 160 170 180 YTPIDRAGLY VPGGRAAYVS TVLMNAIPAR VAGVPRIVIA TPPGAQKAIN PAVLVAAQEV 190 200 210 220 230 240 GVQEIYRVGG AQAIAALAYG TETIPKVDVI TGPGNIYVTL AKKLVYGNVG IDSLAGPSEV 250 260 270 280 290 300 LIIADEGANP VHVATDMLAQ AEHDPMAAAI LFTTDPALAK NVQVAVERQL VDHPRRIDTE 310 320 330 340 350 360 KAIAHYGLIV LVESLDAAAE LSNEFAPEHL ELEVKDPWAV LPNIRHAGAI FLGYSTPEAV 370 380 390 400 410 420 GDYLAGPNHT LPTSGAARYA SALSVETFLK HSSIIQYSQT ALNKVAGAID ALATAEGLPS 430 HADSVKRRIQ QDE

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB77957.1.
PIR	AI2004.
RefSeq	NP_485631.1.
3D structure databases
HSSP	HSSP built from PDB template 1K75 based on UniProtKB P06988.
ModBase	Search...
Genome annotation databases
GeneID	1105183.
GenomeReviews	Gene locus all1591 in contig BA000019_GR.
KEGG	ana:all1591.
NMPDR	fig|103690.1.peg.1898.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YWL4.
Enzyme and pathway databases
BioCyc	NSP103690:ALL1591-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX2_ANASP

Accession

Primary (citable) accession number: Q8YWL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 1, 2002
Last modified:	November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)