Reviewed, UniProtKB/Swiss-Prot Q8YWD8 (MSRA2_ANASP)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 2
      Short name=Protein-methionine-S-oxide reductase 2
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 2
      Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	alr1675

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Peptide methionine sulfoxide reductase msrA 2 HAMAP MF_01401		PRO_0000138528
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YWD8-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 145350789FDAA98A	FASTA	222	24,358
	10 20 30 40 50 60 MALFGFGKKL ALPTPEKALP GRAQIMPVPA NHYVNKNPLK PPFPDGFEKA LFGLGCFWGA 70 80 90 100 110 120 ERKFWQQQGV YSTAVGYAAG FTPNPTYDEV CTGLTGHNEV VLVVFDPKVI SYTQLLKVFW 130 140 150 160 170 180 ESHNPTQGMR QGNDVGTQYR SGIYVYSEAQ KQLAEASRDA YQQALSSAGY EKITTEILDA 190 200 210 220 PEFYYAEAYH QQYLAKNPNG YCGLGGTNVA CPVGVFESSA NG

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB78041.1.
PIR	AE2015.
RefSeq	NP_485715.1.
3D structure databases
HSSP	HSSP built from PDB template 1FVA based on UniProtKB P54149.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YWD8.
Genome annotation databases
GeneID	1105267.
GenomeReviews	Gene locus alr1675 in contig BA000019_GR.
KEGG	ana:alr1675.
NMPDR	fig|103690.1.peg.1982.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YWD8.
OMA	YHQQYLD.
Enzyme and pathway databases
BioCyc	NSP103690:ALR1675-MON.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_ANASP

Accession

Primary (citable) accession number: Q8YWD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)