Q8YWD8 (MSRA2_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2
Short name=Protein-methionine-S-oxide reductase 2
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2
Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	alr1675

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401		PRO_0000138528
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YWD8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 145350789FDAA98A	FASTA	222	24,358
	10 20 30 40 50 60 MALFGFGKKL ALPTPEKALP GRAQIMPVPA NHYVNKNPLK PPFPDGFEKA LFGLGCFWGA 70 80 90 100 110 120 ERKFWQQQGV YSTAVGYAAG FTPNPTYDEV CTGLTGHNEV VLVVFDPKVI SYTQLLKVFW 130 140 150 160 170 180 ESHNPTQGMR QGNDVGTQYR SGIYVYSEAQ KQLAEASRDA YQQALSSAGY EKITTEILDA 190 200 210 220 PEFYYAEAYH QQYLAKNPNG YCGLGGTNVA CPVGVFESSA NG

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB78041.1.
PIR	AE2015.
RefSeq	NP_485715.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YWD8.
SMR	Q8YWD8. Positions 14-212.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YWD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1105267.
GenomeReviews	Gene locus alr1675 in contig BA000019_GR.
KEGG	ana:alr1675.
NMPDR	fig|103690.1.peg.1982.
PATRIC	22773396. VBINosSp37423_2177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	QETSFEQ.
PhylomeDB	Q8YWD8.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	NSP103690:ALR1675-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_NOSS1

Accession

Primary (citable) accession number: Q8YWD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program