Q8YWD2 (PYRB_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	all1681

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113086

Sequences

	Sequence		Length	Mass (Da)
	Q8YWD2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: AA3DEB7CD0320E21	FASTA	333	36,621
	10 20 30 40 50 60 MPTSTWNRHH VLSLADFTAA EYDIVLKTAA SFQEVLSRRT KKVPALQGQV VANLFFEPST 70 80 90 100 110 120 RTRSSFELAA KRLSADTLNF AASTSSMTKG ETILDTAKTY LAMGTDIMVI RHKEAGVPNA 130 140 150 160 170 180 IAQEMDRLGV RVSVLNAGDG QHEHPSQGLL DLFTICSLID PANPRLELLQ GKKIAIVGDI 190 200 210 220 230 240 LHSRVARSNI WSLIASGAQV HLAAPPTLLP KFFAEYIFGE ETAPPGQLFI HWQLEPALQE 250 260 270 280 290 300 ADFVMTLRLQ KERMTANLLP SLREYHQLFG ITRAKLQLCQ PNVKVLHPGP VNRGVEISSD 310 320 330 LMDDPEFSLI QSQVTSGVAV RMALLYLIGS GKT

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB78047.1.
PIR	AC2016.
RefSeq	NP_485721.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YWD2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YWD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1105273.
GenomeReviews	Gene locus all1681 in contig BA000019_GR.
KEGG	ana:all1681.
NMPDR	fig|103690.1.peg.1988.
PATRIC	22773408. VBINosSp37423_2183.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	LQRERMS.
PhylomeDB	Q8YWD2.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	NSP103690:ALL1681-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_NOSS1

Accession

Primary (citable) accession number: Q8YWD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program