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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:alr1798
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_0000165375Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi103690.alr1798.

Structurei

3D structure databases

ProteinModelPortaliQ8YW18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiPOG091H00ZG.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YW18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQILQLNL EQTSSAAAED TNLDCSLAGY DYVLPPERIA QNPAVPRDSS
60 70 80 90 100
RLLVVNSQTT GKETPPLHQI FRDLPDILRP GDLLIMNNTK VIPARLYGRK
110 120 130 140 150
SSGAEVEILL LEERKFNCWL ALVKPGKRFK KGTQIIFEGL GMRNLGIENS
160 170 180 190 200
PQYSVASPHQ LTATVLETDK ATGGRLLQFD LPEGQSLVQL LDKFGEIPLP
210 220 230 240 250
PYITTSQAAD EQYQTVYAEE PGAIAAPTAG LHFTPELLQK LRDRNINQAF
260 270 280 290 300
ITLHVGVGTF RPVEVEDVAT HQMHEEWIEV PAATVAQIKA TKAAGGRIIA
310 320 330 340 350
VGTTVVRALE GAAASGNLQE FCGKTNLFIY PGYKWQVVEG LITNFHLPRS
360 370 380 390
SLLMLVSALI GRERLLNIYQ EAIASQYRFY SFGDAMLILP EARGVEQ
Length:397
Mass (Da):43,789
Last modified:March 1, 2002 - v1
Checksum:iBBE64999727835F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73497.1.
PIRiAH2030.
RefSeqiWP_010995966.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73497; BAB73497; BAB73497.
KEGGiana:alr1798.
PATRICi22773667. VBINosSp37423_2311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73497.1.
PIRiAH2030.
RefSeqiWP_010995966.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YW18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73497; BAB73497; BAB73497.
KEGGiana:alr1798.
PATRICi22773667. VBINosSp37423_2311.

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiPOG091H00ZG.

Enzyme and pathway databases

UniPathwayiUPA00392.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEA_NOSS1
AccessioniPrimary (citable) accession number: Q8YW18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.