Q8YW05 (GLPK_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	all1811

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Glycerol kinase HAMAP MF_00186		PRO_0000059429
Regions
	Nucleotide binding	414 – 418	5	ATP By similarity
Sites
	Binding site	16	1	Substrate By similarity
	Binding site	20	1	ATP By similarity
	Binding site	86	1	Substrate By similarity
	Binding site	138	1	Substrate By similarity
	Binding site	243	1	Substrate By similarity
	Binding site	265	1	ATP By similarity
	Binding site	313	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YW05 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 795A008A3CB2B86F	FASTA	500	54,911
	10 20 30 40 50 60 MQISSSGYIL ALDLGTTGNR AFIFNNAGKI VAQAYKELTQ HYPQPGWLEH DAEEIWQDTC 70 80 90 100 110 120 WVMKTAIVNA QISPSEIAAI GLTVQRETCL LWDKTTGRPL HKAIVWQDRR TAPLCHQLQE 130 140 150 160 170 180 KGYAQEIYSR TGLVVDAYFS ATKLRWLLDY ITGVDLKNVL AGTIDTWILW KLTGGKVHAT 190 200 210 220 230 240 DHSNASRTML MNLKTGEWDE QLLEILQIPA HILPQIQPSL GKFGVTDTSL LDAAIPITAI 250 260 270 280 290 300 LGDQQAALFG HGCDRPGLMK CTYGTGSFLV AHTGSNIVRS QHQLISTIAW TQADKQENIN 310 320 330 340 350 360 IGYALEGSMF TSGACIQWLR DGIKLIKTAA ETETMANQVA DNGGVYFVPA FSGLGAPYWD 370 380 390 400 410 420 MNARGAFFGI TASVQPQHLV RAVLEAIAYQ VLEVVQAINA SCSSPMQRLI VDGGACENNF 430 440 450 460 470 480 LMQFQADVLG IPVERPTMRD TTVQGAAFAA GLAVGFWDSY TALVNQRQID RIFEPGEGSQ 490 500 NATANFAIWQ KAVKRSLDWV

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73510.1.
PIR	AE2032.
RefSeq	NP_485851.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YW05.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YW05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1105403.
GenomeReviews	Gene locus all1811 in contig BA000019_GR.
KEGG	ana:all1811.
NMPDR	fig|103690.1.peg.2118.
PATRIC	22773691. VBINosSp37423_2323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0554.
HOGENOM	HBG511469.
OMA	ASETERY.
PhylomeDB	Q8YW05.
ProtClustDB	CLSK893231.
Enzyme and pathway databases
BioCyc	NSP103690:ALL1811-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_NOSS1

Accession

Primary (citable) accession number: Q8YW05

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program