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Q8YVS7 (HO1_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme oxygenase 1

EC=1.14.99.3
Gene names
Name:pbsA1
Ordered Locus Names:all1897
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity. Upon overexpression in E.coli with PCB:ferredoxin oxidoreductase, CpeS and either CpcB or PecB permits synthesis of phycocyanin-coupled CpcB or PecB. Ref.2

Catalytic activity

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sequence similarities

Belongs to the heme oxygenase family.

Ontologies

Keywords
   Biological processPhotosynthesis
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme oxidation

Inferred from electronic annotation. Source: InterPro

photosynthesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheme oxygenase (decyclizing) activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Heme oxygenase 1
PRO_0000403173

Sequences

Sequence LengthMass (Da)Tools
Q8YVS7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: D28DA4EEC4DA79BD

FASTA23826,902
        10         20         30         40         50         60 
MSSNLANKLR VGTKKAHTMA ENVGFVKCFL KGVVEKSSYR KLVANFYYVY SAMEEEMEKH 

        70         80         90        100        110        120 
SQHPIVSKIN FSQLNRKQTL EQDLSYYYGA NWREQIQLSP AGEAYVQRIR EISATEPELL 

       130        140        150        160        170        180 
IAHSYTRYLG DLSGGQILKN IAVTAMNLND GQGTAFYEFA DISDEKAFKA KYRQTLDELA 

       190        200        210        220        230 
IDEATGDRIV DEANAAFGMN MKMFQELEGN LIKAIGMMLF NTLTRKRTRG ATELATAE 

« Hide

References

« Hide 'large scale' references
[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.
[2]"Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin:cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena Sp. PCC7120."
Zhao K.H., Su P., Li J., Tu J.M., Zhou M., Bubenzer C., Scheer H.
J. Biol. Chem. 281:8573-8581(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB73596.1.
PIRAC2043.
RefSeqNP_485937.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YVS7.
SMRQ8YVS7. Positions 2-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.all1897.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB73596; BAB73596; BAB73596.
GeneID1105489.
KEGGana:all1897.
PATRIC22773882. VBINosSp37423_2417.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG5398.
HOGENOMHOG000233221.
KOK00510.
OMAQEARMAF.
OrthoDBEOG69PQ2G.

Family and domain databases

Gene3D1.20.910.10. 1 hit.
InterProIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERPTHR10720. PTHR10720. 1 hit.
PfamPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFPIRSF000343. Haem_Oase. 1 hit.
PRINTSPR00088. HAEMOXYGNASE.
SUPFAMSSF48613. SSF48613. 1 hit.
PROSITEPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHO1_NOSS1
AccessionPrimary (citable) accession number: Q8YVS7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families