Q8YVS7 (HO1_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme oxygenase 1
EC=1.14.99.3

Gene names

Name:	pbsA1
Ordered Locus Names:	all1897

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity. Upon overexpression in E.coli with PCB:ferredoxin oxidoreductase, CpeS and either CpcB or PecB permits synthesis of phycocyanin-coupled CpcB or PecB. Ref.2
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Biological process	Photosynthesis
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	heme oxidation Inferred from electronic annotation. Source: InterPro photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Heme oxygenase 1		PRO_0000403173

Sequences

	Sequence		Length	Mass (Da)
	Q8YVS7 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: D28DA4EEC4DA79BD	FASTA	238	26,902
	10 20 30 40 50 60 MSSNLANKLR VGTKKAHTMA ENVGFVKCFL KGVVEKSSYR KLVANFYYVY SAMEEEMEKH 70 80 90 100 110 120 SQHPIVSKIN FSQLNRKQTL EQDLSYYYGA NWREQIQLSP AGEAYVQRIR EISATEPELL 130 140 150 160 170 180 IAHSYTRYLG DLSGGQILKN IAVTAMNLND GQGTAFYEFA DISDEKAFKA KYRQTLDELA 190 200 210 220 230 IDEATGDRIV DEANAAFGMN MKMFQELEGN LIKAIGMMLF NTLTRKRTRG ATELATAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.
[2]	"Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin:cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena Sp. PCC7120." Zhao K.H., Su P., Li J., Tu J.M., Zhou M., Bubenzer C., Scheer H. J. Biol. Chem. 281:8573-8581(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73596.1.
PIR	AC2043.
RefSeq	NP_485937.1. NC_003272.1.
3D structure databases
HSSP	HSSP built from PDB template 1IRM based on UniProtKB P06762.
ProteinModelPortal	Q8YVS7.
SMR	Q8YVS7. Positions 2-224.
ModBase	Search...
Protein-protein interaction databases
STRING	103690.all1897.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB73596; BAB73596; BAB73596.
GeneID	1105489.
KEGG	ana:all1897.
PATRIC	22773882. VBINosSp37423_2417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG5398.
HOGENOM	HOG000233221.
KO	K00510.
OMA	KQFYRAR.
ProtClustDB	CLSK2302152.
Family and domain databases
Gene3D	1.20.910.10. 1 hit.
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
PANTHER	PTHR10720. PTHR10720. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
SUPFAM	SSF48613. Heme_oxygenase. 1 hit.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HO1_NOSS1

Accession

Primary (citable) accession number: Q8YVS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program