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Protein

Heme oxygenase 1

Gene

pbsA1

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae (By similarity). Upon overexpression in E.coli with PCB:ferredoxin oxidoreductase, CpeS and either CpcB or PecB permits synthesis of phycocyanin-coupled CpcB or PecB.By similarity1 Publication

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: InterPro
  2. photosynthesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 1 (EC:1.14.99.3)
Gene namesi
Name:pbsA1
Ordered Locus Names:all1897
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Heme oxygenase 1PRO_0000403173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all1897.

Structurei

3D structure databases

ProteinModelPortaliQ8YVS7.
SMRiQ8YVS7. Positions 2-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
KOiK00510.
OMAiKKSHTMA.
OrthoDBiEOG69PQ2G.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YVS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSNLANKLR VGTKKAHTMA ENVGFVKCFL KGVVEKSSYR KLVANFYYVY
60 70 80 90 100
SAMEEEMEKH SQHPIVSKIN FSQLNRKQTL EQDLSYYYGA NWREQIQLSP
110 120 130 140 150
AGEAYVQRIR EISATEPELL IAHSYTRYLG DLSGGQILKN IAVTAMNLND
160 170 180 190 200
GQGTAFYEFA DISDEKAFKA KYRQTLDELA IDEATGDRIV DEANAAFGMN
210 220 230
MKMFQELEGN LIKAIGMMLF NTLTRKRTRG ATELATAE
Length:238
Mass (Da):26,902
Last modified:March 1, 2002 - v1
Checksum:iD28DA4EEC4DA79BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73596.1.
PIRiAC2043.
RefSeqiNP_485937.1. NC_003272.1.
WP_010996061.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73596; BAB73596; BAB73596.
GeneIDi1105489.
KEGGiana:all1897.
PATRICi22773882. VBINosSp37423_2417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB73596.1.
PIRiAC2043.
RefSeqiNP_485937.1. NC_003272.1.
WP_010996061.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YVS7.
SMRiQ8YVS7. Positions 2-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.all1897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73596; BAB73596; BAB73596.
GeneIDi1105489.
KEGGiana:all1897.
PATRICi22773882. VBINosSp37423_2417.

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
KOiK00510.
OMAiKKSHTMA.
OrthoDBiEOG69PQ2G.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.
  2. "Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin:cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena Sp. PCC7120."
    Zhao K.H., Su P., Li J., Tu J.M., Zhou M., Bubenzer C., Scheer H.
    J. Biol. Chem. 281:8573-8581(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiHO1_NOSS1
AccessioniPrimary (citable) accession number: Q8YVS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.