Q8YVR1 (K6PF2_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphofructokinase 2
EC=2.7.1.11

Alternative name(s):
Phosphofructokinase 2
Phosphohexokinase 2

Gene names

Name:	pfkA2
Ordered Locus Names:	alr1913

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphofructokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological_process	fructose 6-phosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	6-phosphofructokinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	6-phosphofructokinase 2 HAMAP-Rule MF_00339		PRO_0000111930
Regions
	Nucleotide binding	22 – 26	5	ATP By similarity
	Nucleotide binding	160 – 164	5	ATP By similarity
	Nucleotide binding	177 – 193	17	ATP By similarity
Sites
	Active site	133	1	Proton acceptor By similarity
	Metal binding	191	1	Magnesium; via carbonyl oxygen By similarity
	Binding site	168	1	Substrate By similarity
	Binding site	272	1	Substrate By similarity
	Binding site	278	1	Substrate By similarity
	Binding site	281	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YVR1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 40A6C3C266A6E5D0	FASTA	357	38,007
	10 20 30 40 50 60 MRKRIGILTS GGDCPGLNCV IRAVVSHATL TYDWEVLGIP YATQGLRERQ AIALNMHGWD 70 80 90 100 110 120 LRGIDPLLNM GGTILGTINK GDTLAHVDEM LASYQALALD ALIVIGGDGS LGILHELASR 130 140 150 160 170 180 GNWNLVAIPK TIDNDVALTE RAVGFDTAVN TIVDALNRLT FTAASHDRVM IVEVMGRSAG 190 200 210 220 230 240 HLALHAGIAG GADVILIPEI SYTISGLCQH IAELRDRWQR KFAIVVVAEG AKLCLEDVQE 250 260 270 280 290 300 NIASSCAPSK CGRGQYIADQ IAQCSKNLID TRVSVLGHIQ RGGIPSALDR LTATVFGKTA 310 320 330 340 350 VDLIAQGKFG QMVAWQNGEA IPVPIQDVVA QSPLHVNPQG SLVQSARCLG IYVGEKT

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73612.1.
PIR	AC2045.
RefSeq	NP_485953.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YVR1.
ModBase	Search...
Protein-protein interaction databases
STRING	103690.alr1913.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB73612; BAB73612; BAB73612.
GeneID	1105505.
KEGG	ana:alr1913.
PATRIC	22773920. VBINosSp37423_2436.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0205.
HOGENOM	HOG000248869.
KO	K00850.
OMA	NGTQKTA.
ProtClustDB	PRK03202.
Enzyme and pathway databases
UniPathway	UPA00109; UER00182.
Family and domain databases
HAMAP	MF_00339. Phosphofructokinase.
InterPro	IPR012003. ATP_PFK_prok. IPR022953. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. IPR000023. Phosphofructokinase_dom. [Graphical view]
Pfam	PF00365. PFK. 1 hit. [Graphical view]
PIRSF	PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTS	PR00476. PHFRCTKINASE.
SUPFAM	SSF53784. Ppfruckinase. 1 hit.
PROSITE	PS00433. PHOSPHOFRUCTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

K6PF2_NOSS1

Accession

Primary (citable) accession number: Q8YVR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program