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Q8YVR1 (K6PF2_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase 2

EC=2.7.1.11
Alternative name(s):
Phosphofructokinase 2
Phosphohexokinase 2
Gene names
Name:pfkA2
Ordered Locus Names:alr1913
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termAllosteric enzyme
Complete proteome
Gene Ontology (GO)
   Biological_processfructose 6-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phosphofructokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3573576-phosphofructokinase 2 HAMAP-Rule MF_00339
PRO_0000111930

Regions

Nucleotide binding22 – 265ATP By similarity
Nucleotide binding160 – 1645ATP By similarity
Nucleotide binding177 – 19317ATP By similarity

Sites

Active site1331Proton acceptor By similarity
Metal binding1911Magnesium; via carbonyl oxygen By similarity
Binding site1681Substrate By similarity
Binding site2721Substrate By similarity
Binding site2781Substrate By similarity
Binding site2811Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YVR1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 40A6C3C266A6E5D0

FASTA35738,007
        10         20         30         40         50         60 
MRKRIGILTS GGDCPGLNCV IRAVVSHATL TYDWEVLGIP YATQGLRERQ AIALNMHGWD 

        70         80         90        100        110        120 
LRGIDPLLNM GGTILGTINK GDTLAHVDEM LASYQALALD ALIVIGGDGS LGILHELASR 

       130        140        150        160        170        180 
GNWNLVAIPK TIDNDVALTE RAVGFDTAVN TIVDALNRLT FTAASHDRVM IVEVMGRSAG 

       190        200        210        220        230        240 
HLALHAGIAG GADVILIPEI SYTISGLCQH IAELRDRWQR KFAIVVVAEG AKLCLEDVQE 

       250        260        270        280        290        300 
NIASSCAPSK CGRGQYIADQ IAQCSKNLID TRVSVLGHIQ RGGIPSALDR LTATVFGKTA 

       310        320        330        340        350 
VDLIAQGKFG QMVAWQNGEA IPVPIQDVVA QSPLHVNPQG SLVQSARCLG IYVGEKT 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB73612.1.
PIRAC2045.
RefSeqNP_485953.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YVR1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.alr1913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB73612; BAB73612; BAB73612.
GeneID1105505.
KEGGana:alr1913.
PATRIC22773920. VBINosSp37423_2436.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMAWVGLMED.
OrthoDBEOG644ZRM.
ProtClustDBPRK03202.

Enzyme and pathway databases

UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF2_NOSS1
AccessionPrimary (citable) accession number: Q8YVR1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways