Reviewed, UniProtKB/Swiss-Prot Q8YVQ0 (AROB_ANASP)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	alr1924

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. HAMAP MF_00110 Divalent metal cations By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140706

Sequences

	Sequence		Length	Mass (Da)
	Q8YVQ0-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 88C8546056929D9C	FASTA	363	39,342
	10 20 30 40 50 60 MTSVINVNLP TQSYEIAIAP ASLDQIGQSL AGLKLGKKVL LVSNPTIFKH FGKVAVDSLE 70 80 90 100 110 120 AAGFQVASYS LPAGERYKTL NSIQKLYDIA LENRLERSST MVALGGGVIG DMTGFAAATW 130 140 150 160 170 180 LRGINVVQVP TTLLAMVDSA IGGKTGVNHP HGKNLIGAFH QPRFVLIDPQ VLKTLPVREF 190 200 210 220 230 240 RAGMAEVIKY GVIWDAELFN QLEQSKRLDQ LRYIKPELVD AILTRSCQAK ADVVGKDEKE 250 260 270 280 290 300 GGLRAILNYG HTVGHAVESL TNYRLLKHGE AVGIGMVAAG QIAVNLELWQ QADADRQNAL 310 320 330 340 350 360 IEKAGLPTKL PVGLDIEGII EALQLDKKVK DGKVRFVLPT QIGVVTVTDE VTSDHIRQVL QQM

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73623.1.
PIR	AF2046.
RefSeq	NP_485964.1.
3D structure databases
SMR	Q8YVQ0. Positions 14-360.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YVQ0.
Genome annotation databases
GeneID	1105516.
GenomeReviews	Gene locus alr1924 in contig BA000019_GR.
KEGG	ana:alr1924.
NMPDR	fig|103690.1.peg.2231.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	VAAFCWQ.
PhylomeDB	Q8YVQ0.
Enzyme and pathway databases
BioCyc	NSP103690:ALR1924-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ANASP

Accession

Primary (citable) accession number: Q8YVQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)