Reviewed, UniProtKB/Swiss-Prot Q8YVC1 (AROE_ANASP)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	alr2057

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000135989
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YVC1-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 0C246CD85C2099C2	FASTA	289	31,538
	10 20 30 40 50 60 MITGKTKLLG VIGHPVEHSL SPVMHNAAIA QLGLDYVYLP FPIAPDNLEA AIALLATIGV 70 80 90 100 110 120 VGFSVTIPHK QAIIPLLSEI SPVAQAIGAV NTVTRQNNQW VGTNTDIEGF IAPLQTTYKR 130 140 150 160 170 180 DWSQQIAVIL GNGGAARAVV AGCYQLGFAE IHVVGRNVQR LEEFRHSWEN SPIAENLQVH 190 200 210 220 230 240 TWDYLAKLIP QANLLVNTTP IGMYPQVDES PLSAEELVNL QTGTIAYDLI YIPKPTQFLQ 250 260 270 280 KAQQQGAIII DGLEMLVQQG VAALKIWLQQ DDIPVDVMRQ ALIKHLGLK

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73756.1.
PIR	AC2063.
RefSeq	NP_486097.1.
3D structure databases
SMR	Q8YVC1. Positions 1-287.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YVC1.
Genome annotation databases
GeneID	1105652.
GenomeReviews	Gene locus alr2057 in contig BA000019_GR.
KEGG	ana:alr2057.
NMPDR	fig|103690.1.peg.2364.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	MLINATT.
PhylomeDB	Q8YVC1.
Enzyme and pathway databases
BioCyc	NSP103690:ALR2057-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ANASP

Accession

Primary (citable) accession number: Q8YVC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)