Reviewed, UniProtKB/Swiss-Prot Q8YUR7 (PUR7_ANASP)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	alr2268

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_0000100796

Sequences

	Sequence		Length	Mass (Da)
	Q8YUR7-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F4919EC9D6D959C3	FASTA	245	27,740
	10 20 30 40 50 60 MSVHSKLYEG KAKILYTTDE PEVLLADFKD DATAFNAQKR GSIIGKGRIN CSISSQLFQQ 70 80 90 100 110 120 LEASGIKTHF IDSPAPNQMR VKAVKIIPLE VVIRNIAAGS LSQQTGIELG TVLKQPLVEF 130 140 150 160 170 180 YYKNDQLGDP LLTRDRLLLM ELATAEQVEE ITHLALQIND FLKNFWQNCG ITLVDFKLEF 190 200 210 220 230 240 GLDSQQQILL ADEISPDTCR LWNTTEADPN RRVMDKDRFR RDLGNVEDAY QEVLQRVLTA VEIKN

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB73967.1.
PIR	AE2089.
RefSeq	NP_486308.1.
3D structure databases
SMR	Q8YUR7. Positions 1-238.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YUR7.
Genome annotation databases
GeneID	1105865.
GenomeReviews	Gene locus alr2268 in contig BA000019_GR.
KEGG	ana:alr2268.
NMPDR	fig|103690.1.peg.2575.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG306070.
OMA	TAFNAQK.
PhylomeDB	Q8YUR7.
Enzyme and pathway databases
BioCyc	NSP103690:ALR2268-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_ANASP

Accession

Primary (citable) accession number: Q8YUR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)