Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8YUQ7 (Q8YUQ7_NOSS1) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Ordered Locus Names:alr2278 EMBL BAB73977.1
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP] EMBL BAB73977.1
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding11Sodium; via amide nitrogen PDB 3TF9
Metal binding441Sodium; via carbonyl oxygen PDB 3TF9
Metal binding481Sodium PDB 3TF9
Metal binding1051Iron (heme axial ligand); via tele nitrogen PDB 2O09 PDB 2O0C PDB 2O0G PDB 3TF8 PDB 3TF9 PDB 3TFA PDB 3TFD PDB 3TFE PDB 3TFF PDB 3TFG

Sequences

Sequence LengthMass (Da)Tools
Q8YUQ7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 34C54119F22AACC4

FASTA18921,192
        10         20         30         40         50         60 
MYGLVNKAIQ DMISKHHGED TWEAIKQKAG LEDIDFFVGM EAYSDDVTYH LVGAASEVLG 

        70         80         90        100        110        120 
KPAEELLIAF GEYWVTYTSE EGYGELLASA GDSLPEFMEN LDNLHARVGL SFPQLRPPAF 

       130        140        150        160        170        180 
ECQHTSSKSM ELHYQSTRCG LAPMVLGLLH GLGKRFQTKV EVTQTAFRET GEDHDIFSIK 


YEDSNLYDD 

« Hide

References

« Hide 'large scale' references
[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.
[2]"NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism."
Ma X., Sayed N., Beuve A., van den Akker F.
EMBO J. 26:578-588(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH HEME.
[3]"Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase."
Martin F., Baskaran P., Ma X., Dunten P.W., Schaefer M., Stasch J.P., Beuve A., van den Akker F.
J. Biol. Chem. 285:22651-22657(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
[4]"Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain."
Winter M.B., Herzik M.A., Kuriyan J., Marletta M.A.
Proc. Natl. Acad. Sci. U.S.A. 108:E881-E889(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH HEME AND SODIUM.
[5]"Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes."
Kumar V., Martin F., Hahn M.G., Schaefer M., Stamler J.S., Stasch J.P., van den Akker F.
Biochemistry 52:3601-3608(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1-182.
[6]"Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics."
von Wantoch Rekowski M., Kumar V., Zhou Z., Moschner J., Marazioti A., Bantzi M., Spyroulias G.A., van den Akker F., Giannis A., Papapetropoulos A.
J. Med. Chem. 56:8948-8952(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB73977.1.
PIRAG2090.
RefSeqNP_486318.1. NC_003272.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2O09X-ray2.10A/B1-189[»]
2O0CX-ray2.60A/B1-189[»]
2O0GX-ray2.51A/B1-189[»]
3L6JX-ray2.30A/B1-189[»]
3TF8X-ray2.13A/B1-189[»]
3TF9X-ray2.59A/B1-189[»]
3TFAX-ray2.27A/B1-189[»]
3TFDX-ray1.96A/B1-189[»]
3TFEX-ray1.99A/B1-189[»]
3TFFX-ray1.94A/B1-189[»]
3TFGX-ray1.90A/B1-189[»]
4IAEX-ray2.05A/B1-189[»]
4IAHX-ray2.80A/B1-182[»]
4IAMX-ray1.99A/B1-182[»]
4JQHX-ray2.30A/B1-189[»]
ProteinModelPortalQ8YUQ7.
SMRQ8YUQ7. Positions 1-182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.alr2278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB73977; BAB73977; BAB73977.
GeneID1105875.
KEGGana:alr2278.
PATRIC22774726. VBINosSp37423_2830.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG261245.
HOGENOMHOG000290574.
OMAVIREVAM.
OrthoDBEOG6384JV.

Family and domain databases

InterProIPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view]
PfamPF07700. HNOB. 1 hit.
[Graphical view]
SUPFAMSSF111126. SSF111126. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8YUQ7.

Entry information

Entry nameQ8YUQ7_NOSS1
AccessionPrimary (citable) accession number: Q8YUQ7
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)