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Q8YUQ7

- Q8YUQ7_NOSS1

UniProt

Q8YUQ7 - Q8YUQ7_NOSS1

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Protein
Submitted name: Alr2278 protein
Gene
alr2278
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1 – 11Sodium; via amide nitrogenImported
Metal bindingi44 – 441Sodium; via carbonyl oxygenImported
Metal bindingi48 – 481SodiumImported
Metal bindingi105 – 1051Iron (heme axial ligand); via tele nitrogenImported

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

HemeImported, Iron, Metal-binding, SodiumImported

Names & Taxonomyi

Protein namesi
Submitted name:
Alr2278 proteinImported
Gene namesi
Ordered Locus Names:alr2278Imported
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)Imported
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi103690.alr2278.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O09X-ray2.10A/B1-189[»]
2O0CX-ray2.60A/B1-189[»]
2O0GX-ray2.51A/B1-189[»]
3L6JX-ray2.30A/B1-189[»]
3TF8X-ray2.13A/B1-189[»]
3TF9X-ray2.59A/B1-189[»]
3TFAX-ray2.27A/B1-189[»]
3TFDX-ray1.96A/B1-189[»]
3TFEX-ray1.99A/B1-189[»]
3TFFX-ray1.94A/B1-189[»]
3TFGX-ray1.90A/B1-189[»]
4IAEX-ray2.05A/B1-189[»]
4IAHX-ray2.80A/B1-182[»]
4IAMX-ray1.99A/B1-182[»]
4JQHX-ray2.30A/B1-189[»]
ProteinModelPortaliQ8YUQ7.
SMRiQ8YUQ7. Positions 1-182.

Miscellaneous databases

EvolutionaryTraceiQ8YUQ7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG261245.
HOGENOMiHOG000290574.
OMAiVIREVAM.
OrthoDBiEOG6384JV.

Family and domain databases

InterProiIPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view]
PfamiPF07700. HNOB. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YUQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MYGLVNKAIQ DMISKHHGED TWEAIKQKAG LEDIDFFVGM EAYSDDVTYH    50
LVGAASEVLG KPAEELLIAF GEYWVTYTSE EGYGELLASA GDSLPEFMEN 100
LDNLHARVGL SFPQLRPPAF ECQHTSSKSM ELHYQSTRCG LAPMVLGLLH 150
GLGKRFQTKV EVTQTAFRET GEDHDIFSIK YEDSNLYDD 189
Length:189
Mass (Da):21,192
Last modified:March 1, 2002 - v1
Checksum:i34C54119F22AACC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB73977.1.
PIRiAG2090.
RefSeqiNP_486318.1. NC_003272.1.
WP_010996435.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73977; BAB73977; BAB73977.
GeneIDi1105875.
KEGGiana:alr2278.
PATRICi22774726. VBINosSp37423_2830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB73977.1 .
PIRi AG2090.
RefSeqi NP_486318.1. NC_003272.1.
WP_010996435.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2O09 X-ray 2.10 A/B 1-189 [» ]
2O0C X-ray 2.60 A/B 1-189 [» ]
2O0G X-ray 2.51 A/B 1-189 [» ]
3L6J X-ray 2.30 A/B 1-189 [» ]
3TF8 X-ray 2.13 A/B 1-189 [» ]
3TF9 X-ray 2.59 A/B 1-189 [» ]
3TFA X-ray 2.27 A/B 1-189 [» ]
3TFD X-ray 1.96 A/B 1-189 [» ]
3TFE X-ray 1.99 A/B 1-189 [» ]
3TFF X-ray 1.94 A/B 1-189 [» ]
3TFG X-ray 1.90 A/B 1-189 [» ]
4IAE X-ray 2.05 A/B 1-189 [» ]
4IAH X-ray 2.80 A/B 1-182 [» ]
4IAM X-ray 1.99 A/B 1-182 [» ]
4JQH X-ray 2.30 A/B 1-189 [» ]
ProteinModelPortali Q8YUQ7.
SMRi Q8YUQ7. Positions 1-182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr2278.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB73977 ; BAB73977 ; BAB73977 .
GeneIDi 1105875.
KEGGi ana:alr2278.
PATRICi 22774726. VBINosSp37423_2830.

Phylogenomic databases

eggNOGi NOG261245.
HOGENOMi HOG000290574.
OMAi VIREVAM.
OrthoDBi EOG6384JV.

Miscellaneous databases

EvolutionaryTracei Q8YUQ7.

Family and domain databases

InterProi IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view ]
Pfami PF07700. HNOB. 1 hit.
[Graphical view ]
SUPFAMi SSF111126. SSF111126. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.
  2. "NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism."
    Ma X., Sayed N., Beuve A., van den Akker F.
    EMBO J. 26:578-588(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH HEME.
  3. "Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase."
    Martin F., Baskaran P., Ma X., Dunten P.W., Schaefer M., Stasch J.P., Beuve A., van den Akker F.
    J. Biol. Chem. 285:22651-22657(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
  4. "Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain."
    Winter M.B., Herzik M.A., Kuriyan J., Marletta M.A.
    Proc. Natl. Acad. Sci. U.S.A. 108:E881-E889(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH HEME AND SODIUM.
  5. "Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes."
    Kumar V., Martin F., Hahn M.G., Schaefer M., Stamler J.S., Stasch J.P., van den Akker F.
    Biochemistry 52:3601-3608(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1-182.
  6. "Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics."
    von Wantoch Rekowski M., Kumar V., Zhou Z., Moschner J., Marazioti A., Bantzi M., Spyroulias G.A., van den Akker F., Giannis A., Papapetropoulos A.
    J. Med. Chem. 56:8948-8952(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

Entry informationi

Entry nameiQ8YUQ7_NOSS1
AccessioniPrimary (citable) accession number: Q8YUQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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