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Q8YUQ7

- Q8YUQ7_NOSS1

UniProt

Q8YUQ7 - Q8YUQ7_NOSS1

Protein
Submitted name:

Alr2278 protein

Gene

alr2278

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi105 – 1051Iron (heme axial ligand); via tele nitrogenImported

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    HemeImported, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alr2278 proteinImported
    Gene namesi
    Ordered Locus Names:alr2278Imported
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)Imported
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.alr2278.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2O09X-ray2.10A/B1-189[»]
    2O0CX-ray2.60A/B1-189[»]
    2O0GX-ray2.51A/B1-189[»]
    3L6JX-ray2.30A/B1-189[»]
    3TF8X-ray2.13A/B1-189[»]
    3TF9X-ray2.59A/B1-189[»]
    3TFAX-ray2.27A/B1-189[»]
    3TFDX-ray1.96A/B1-189[»]
    3TFEX-ray1.99A/B1-189[»]
    3TFFX-ray1.94A/B1-189[»]
    3TFGX-ray1.90A/B1-189[»]
    4IAEX-ray2.05A/B1-189[»]
    4IAHX-ray2.80A/B1-182[»]
    4IAMX-ray1.99A/B1-182[»]
    4JQHX-ray2.30A/B1-189[»]
    ProteinModelPortaliQ8YUQ7.
    SMRiQ8YUQ7. Positions 1-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8YUQ7.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG261245.
    HOGENOMiHOG000290574.
    OMAiVIREVAM.
    OrthoDBiEOG6384JV.

    Family and domain databases

    InterProiIPR011644. Heme_NO-bd.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view]
    PfamiPF07700. HNOB. 1 hit.
    [Graphical view]
    SUPFAMiSSF111126. SSF111126. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YUQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGLVNKAIQ DMISKHHGED TWEAIKQKAG LEDIDFFVGM EAYSDDVTYH    50
    LVGAASEVLG KPAEELLIAF GEYWVTYTSE EGYGELLASA GDSLPEFMEN 100
    LDNLHARVGL SFPQLRPPAF ECQHTSSKSM ELHYQSTRCG LAPMVLGLLH 150
    GLGKRFQTKV EVTQTAFRET GEDHDIFSIK YEDSNLYDD 189
    Length:189
    Mass (Da):21,192
    Last modified:March 1, 2002 - v1
    Checksum:i34C54119F22AACC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB73977.1.
    PIRiAG2090.
    RefSeqiNP_486318.1. NC_003272.1.
    WP_010996435.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB73977; BAB73977; BAB73977.
    GeneIDi1105875.
    KEGGiana:alr2278.
    PATRICi22774726. VBINosSp37423_2830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB73977.1 .
    PIRi AG2090.
    RefSeqi NP_486318.1. NC_003272.1.
    WP_010996435.1. NC_003272.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2O09 X-ray 2.10 A/B 1-189 [» ]
    2O0C X-ray 2.60 A/B 1-189 [» ]
    2O0G X-ray 2.51 A/B 1-189 [» ]
    3L6J X-ray 2.30 A/B 1-189 [» ]
    3TF8 X-ray 2.13 A/B 1-189 [» ]
    3TF9 X-ray 2.59 A/B 1-189 [» ]
    3TFA X-ray 2.27 A/B 1-189 [» ]
    3TFD X-ray 1.96 A/B 1-189 [» ]
    3TFE X-ray 1.99 A/B 1-189 [» ]
    3TFF X-ray 1.94 A/B 1-189 [» ]
    3TFG X-ray 1.90 A/B 1-189 [» ]
    4IAE X-ray 2.05 A/B 1-189 [» ]
    4IAH X-ray 2.80 A/B 1-182 [» ]
    4IAM X-ray 1.99 A/B 1-182 [» ]
    4JQH X-ray 2.30 A/B 1-189 [» ]
    ProteinModelPortali Q8YUQ7.
    SMRi Q8YUQ7. Positions 1-182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr2278.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB73977 ; BAB73977 ; BAB73977 .
    GeneIDi 1105875.
    KEGGi ana:alr2278.
    PATRICi 22774726. VBINosSp37423_2830.

    Phylogenomic databases

    eggNOGi NOG261245.
    HOGENOMi HOG000290574.
    OMAi VIREVAM.
    OrthoDBi EOG6384JV.

    Miscellaneous databases

    EvolutionaryTracei Q8YUQ7.

    Family and domain databases

    InterProi IPR011644. Heme_NO-bd.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view ]
    Pfami PF07700. HNOB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111126. SSF111126. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576Imported.
    2. "NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism."
      Ma X., Sayed N., Beuve A., van den Akker F.
      EMBO J. 26:578-588(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH HEME.
    3. "Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase."
      Martin F., Baskaran P., Ma X., Dunten P.W., Schaefer M., Stasch J.P., Beuve A., van den Akker F.
      J. Biol. Chem. 285:22651-22657(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
    4. "Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain."
      Winter M.B., Herzik M.A., Kuriyan J., Marletta M.A.
      Proc. Natl. Acad. Sci. U.S.A. 108:E881-E889(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH HEME.
    5. "Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes."
      Kumar V., Martin F., Hahn M.G., Schaefer M., Stamler J.S., Stasch J.P., van den Akker F.
      Biochemistry 52:3601-3608(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1-182.
    6. "Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics."
      von Wantoch Rekowski M., Kumar V., Zhou Z., Moschner J., Marazioti A., Bantzi M., Spyroulias G.A., van den Akker F., Giannis A., Papapetropoulos A.
      J. Med. Chem. 56:8948-8952(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

    Entry informationi

    Entry nameiQ8YUQ7_NOSS1
    AccessioniPrimary (citable) accession number: Q8YUQ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3