Q8YU19 (DAPB_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	alr2542

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141406

Sequences

	Sequence		Length	Mass (Da)
	Q8YU19 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: FA1D7C90DDFEDD6B	FASTA	278	29,522
	10 20 30 40 50 60 MTNQAPIPVI VNGAAGKMGR EVVKAVAQAP DLNLLGAIDS SPEHQGKDAG ELAGLSEPLE 70 80 90 100 110 120 VPITNQLEPM LGYVAGERQG PPGVIVDFTH PDSVYDNVRS AIAYGIRPVV GTTGLSPAQI 130 140 150 160 170 180 QNLADFAEKA STGCLIIPNF SIGMVLLQQA AVTASQYFDH VEIIELHHNQ KADAPSGTAI 190 200 210 220 230 240 QTAELLAELG KTFNSAIVEE TEKIPGARGS LAEEGIRIHS VRLPGLIAHQ EVIFGAPGQI 250 260 270 YTLRHDTSDR ACYMPGVLLA IRKVLQLKSL VYGLEKIL

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB74241.1.
PIR	AG2123.
RefSeq	NP_486582.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YU19.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YU19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1106139.
GenomeReviews	Gene locus alr2542 in contig BA000019_GR.
KEGG	ana:alr2542.
NMPDR	fig|103690.1.peg.2849.
PATRIC	22775292. VBINosSp37423_3111.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	MVRVILN.
PhylomeDB	Q8YU19.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	NSP103690:ALR2542-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_NOSS1

Accession

Primary (citable) accession number: Q8YU19

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program