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Protein

Histidine kinase

Gene

alr2682

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro
  3. protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine kinaseSAAS annotation (EC:2.7.13.3SAAS annotation)
Gene namesi
Ordered Locus Names:alr2682Imported
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)Imported
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi103690.alr2682.

Structurei

3D structure databases

ProteinModelPortaliQ8YTN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains histidine kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000263148.
OMAiEFEQMES.
OrthoDBiEOG69SK6D.

Family and domain databases

Gene3Di3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_C.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013656. PAS_4.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF08448. PAS_4. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YTN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIPGYRLD EELYNGSRTL VYRGYREIDS LPVVVKLLKN PYPSFNELIH
60 70 80 90 100
FRNQYTITKN LHYPGIIQTY SLEPYKNGYA LVMEDFGGVS LKDYFGKDHH
110 120 130 140 150
VASLQEFLEI AIALCNTLDV LYRECIIHKD IKPANILINP ETKQIKLIDF
160 170 180 190 200
SIASLLPRET QIVINKNILE GTLAYISPEQ TGRMNRGIDY RTDFYSLGVT
210 220 230 240 250
FYELLTAELP FVSRDPMELI HSHIAKLPEK LRSGREREIP KVICDIVMKL
260 270 280 290 300
MAKNAENRYQ SALGLKFDLE NCLNQLQETG KIQDFEIAQR DVCDRFLITD
310 320 330 340 350
KLYGRDTEVE ALLQAFERVS LGATEMMLIA GASGIGKTAV INEVHKPIVR
360 370 380 390 400
QRGYFIKGKF DQFQRNIPLS AFVQAFRDLI AQLLTESDTQ IQRWRNQILE
410 420 430 440 450
AVGENGQIII EVIPELSRII GEQASVLEIS GTAAQSRFNL LFQKFTQVFT
460 470 480 490 500
TAEHPLVIFL DDLQWADSAS LKLMQLLMAD TGHLFLIGAY RDNEVSPVHP
510 520 530 540 550
LMVTLNQIEK TATIINTITL SALTQRQINQ LIADTFKCTE DLALPLSALI
560 570 580 590 600
FQKTQGNPFF ATQLLKQLYQ DKLIDFNFQS GFWQCDIAKV KNQVVTDDVV
610 620 630 640 650
EFMVAQLRRL PEATQKVLQL AACIGNQFDL ATLAIVSEQS KIETAASLCK
660 670 680 690 700
ALQEGLILPL SEIYKFYQDS SLENTEHTAK NIEAQLAAFN VEEKTTIYKF
710 720 730 740 750
LHDRVQQAAS YLIPEEQKQL THLKVGQLLL ENTPLAQQSE RIFEIVGQLN
760 770 780 790 800
CAIPLITEQK KCQQLAQLNL NAGRKAKEAI AYSASLQYFN QGIELIISDG
810 820 830 840 850
WKNAHDLTLN LYQDAAEAAF LNNEFEQMES LIEVVIQEAK NLLDKVKVHE
860 870 880 890 900
IQLQSYQVQG QMLKAIKIGC KTLQELGIVL SEDITSHDIN QAIENTLLIL
910 920 930 940 950
GNRQIESLID LPMMIEPQAL FALKIMISLT PSVHQAAPQL FPIIACEQVN
960 970 980 990 1000
LSLKYGNAAL SAPGYADFAI VLNAVFNELD KGYEFGQLAL KIVDKFAAKY
1010 1020 1030 1040 1050
VQSMTSFKVA AFNQINKLHI RDAINLLKES YSFGLEFGDF VHIIVATFFR
1060 1070 1080 1090 1100
LFYTYLTSSE KLDDLLKEIK MYEVNFASSQ SFSIRFRMLR QSIEILTGVS
1110 1120 1130 1140 1150
HDSDLLMDEH WNEENILPIL LQENDEFTFH EFYLIKLINS YLFNDSLTAV
1160 1170 1180 1190 1200
HYAEQGDSHL KGGAGMLSVS VFYYYDSLAR LALYSQVEPS EQTRLLLRVD
1210 1220 1230 1240 1250
ENQQHLKLRA TVAPMNFQHK FDLVEAERHR ALGQRFEAID LYESAIAGAK
1260 1270 1280 1290 1300
ANEYILEEAL ANELAAKFYL EWGKEKVAQA YMQEAYYCYF SWGAKAKTED
1310 1320 1330 1340 1350
LEKRYPHLLQ PILQQQRINF HPLETISWSG TSLSIHTSNA DSTSISNMLD
1360 1370 1380 1390 1400
FSSILKAAQA ISSSLKLDQL IANLTRIILE NSGAKKSALI LLQENTWQVK
1410 1420 1430 1440 1450
AITLINHEQI QPIFESQSLD TCQDIPVNII NYVKNTRQTV VIDNCKTDIP
1460 1470 1480 1490 1500
GLMGEYMQQI QPQSVLSTPI INQGRLVGVL YLENKLTQGV FTRDRLSVIN
1510 1520 1530 1540 1550
FLCTQAAIAL ENAQLYNHLQ EREQFLSSIY EGIGCLVFVI DVRDNGRLEY
1560 1570 1580 1590 1600
TGWSKSCELA IGIPTSEVLG KTPQELMAPD QGAAVEQKYL RCFQTGIPIT
1610 1620 1630 1640 1650
YEECLTFNDQ ETWWLTTLSP LKDETDKVYR LVGTTINISE QQAALRERKQ
1660 1670 1680 1690 1700
AEEAVTEKSQ ALETALEDLQ QAQLQIVQSE KMSALGNLVA GVAHEMNNPL
1710 1720 1730 1740 1750
GFISATLKQT KPNFTDIIGH LQLYQELIEN PGDEIQDHAE EIDLDYLLED
1760 1770 1780 1790 1800
LPKTIDAMVM ACDRLKNIST SLRTFSRADK DYKVPFNLHQ GIDSTILILK
1810 1820 1830 1840 1850
HRFKANDKRP AIEVITEYGD LPLIECFPGQ LNQVFMNILA NAIDALDESN
1860 1870 1880 1890 1900
TGRSFADIQA KPNRILITTL MVDKCVNISI SDNGKGMTKE VQEKIFDHLF
1910 1920 1930 1940
TTKAVGKGTG LGLAIARQIV EETHNGKLSC HSILGEGTDF MIEIPV
Length:1,946
Mass (Da):220,010
Last modified:March 1, 2002 - v1
Checksum:i11EF82F329FF3446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB74381.1.
PIRiAC2141.
RefSeqiNP_486722.1. NC_003272.1.
WP_010996838.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB74381; BAB74381; BAB74381.
KEGGiana:alr2682.
PATRICi22775595. VBINosSp37423_3262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB74381.1.
PIRiAC2141.
RefSeqiNP_486722.1. NC_003272.1.
WP_010996838.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YTN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr2682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB74381; BAB74381; BAB74381.
KEGGiana:alr2682.
PATRICi22775595. VBINosSp37423_3262.

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000263148.
OMAiEFEQMES.
OrthoDBiEOG69SK6D.

Family and domain databases

Gene3Di3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_C.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013656. PAS_4.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF08448. PAS_4. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576Imported.

Entry informationi

Entry nameiQ8YTN2_NOSS1
AccessioniPrimary (citable) accession number: Q8YTN2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.