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Protein

Circadian clock protein KaiB

Gene

kaiB

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Circadian clock protein KaiB
Gene namesi
Name:kaiB
Ordered Locus Names:alr2885
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23R → A: Induces a strong decrease the interaction with KaiC. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177611 – 108Circadian clock protein KaiBAdd BLAST108

Interactioni

Subunit structurei

Homodimer. Component of the KaiABC complex, at least composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. The KaiABC complex also interacts with SasA (By similarity).By similarity

Protein-protein interaction databases

STRINGi103690.alr2885.

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 16Combined sources9
Helixi19 – 36Combined sources18
Beta strandi39 – 46Combined sources8
Turni47 – 49Combined sources3
Helixi62 – 65Combined sources4
Helixi66 – 68Combined sources3
Helixi71 – 82Combined sources12
Beta strandi87 – 94Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R5PX-ray2.20A/B1-108[»]
ProteinModelPortaliQ8YT41.
SMRiQ8YT41.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8YT41.

Family & Domainsi

Sequence similaritiesi

Belongs to the KaiB family.Curated

Phylogenomic databases

eggNOGiENOG4108ZGN. Bacteria.
ENOG4111NNQ. LUCA.
HOGENOMiHOG000230415.
KOiK08481.
OMAiTPNSMRA.
OrthoDBiPOG091H14Y8.

Family and domain databases

CDDicd02978. KaiB_like. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_01835. KaiB. 1 hit.
InterProiIPR013474. Circ_KaiB.
IPR011649. KaiB_domain.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07689. KaiB. 1 hit.
[Graphical view]
SMARTiSM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02654. circ_KaiB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YT41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKARKTYVL KLYVAGNTPN SVRALKTLKN ILEQEFQGIY ALKVIDVLKN
60 70 80 90 100
PQLAEEDKIL ATPTLSKILP PPVRKIIGDL SDRERVLIGL DLLYEELTEE

DWEAQSNL
Length:108
Mass (Da):12,276
Last modified:March 1, 2002 - v1
Checksum:i6DCFFC8184BA28B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071284 Genomic DNA. Translation: BAB85868.1.
BA000019 Genomic DNA. Translation: BAB74584.1.
PIRiAF2166.
RefSeqiWP_010997036.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB74584; BAB74584; BAB74584.
KEGGiana:alr2885.
PATRICi22776052. VBINosSp37423_3488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071284 Genomic DNA. Translation: BAB85868.1.
BA000019 Genomic DNA. Translation: BAB74584.1.
PIRiAF2166.
RefSeqiWP_010997036.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R5PX-ray2.20A/B1-108[»]
ProteinModelPortaliQ8YT41.
SMRiQ8YT41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr2885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB74584; BAB74584; BAB74584.
KEGGiana:alr2885.
PATRICi22776052. VBINosSp37423_3488.

Phylogenomic databases

eggNOGiENOG4108ZGN. Bacteria.
ENOG4111NNQ. LUCA.
HOGENOMiHOG000230415.
KOiK08481.
OMAiTPNSMRA.
OrthoDBiPOG091H14Y8.

Miscellaneous databases

EvolutionaryTraceiQ8YT41.

Family and domain databases

CDDicd02978. KaiB_like. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_01835. KaiB. 1 hit.
InterProiIPR013474. Circ_KaiB.
IPR011649. KaiB_domain.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07689. KaiB. 1 hit.
[Graphical view]
SMARTiSM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02654. circ_KaiB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAIB_NOSS1
AccessioniPrimary (citable) accession number: Q8YT41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.