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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei55Proton donorUniRule annotation1
Binding sitei79Beta-alanineUniRule annotation1
Binding sitei79PantoateUniRule annotation1
Binding sitei178PantoateUniRule annotation1
Binding sitei201ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 55ATPUniRule annotation8
Nucleotide bindingi172 – 175ATPUniRule annotation4
Nucleotide bindingi209 – 212ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Ligase, Multifunctional enzyme, Transferase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:alr2936
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397871 – 534Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST534

Proteomic databases

PRIDEiQ8YSZ3

Interactioni

Protein-protein interaction databases

STRINGi103690.alr2936

Structurei

3D structure databases

ProteinModelPortaliQ8YSZ3
SMRiQ8YSZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 302Pantoate--beta-alanine ligaseUniRule annotationAdd BLAST302
Regioni303 – 534Cytidylate kinaseUniRule annotationAdd BLAST232

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT Bacteria
COG0283 LUCA
COG0414 LUCA
HOGENOMiHOG000233355
KOiK13799
OMAiLGEKDWQ
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00238 Cytidyl_kinase_type1, 1 hit
MF_00158 PanC, 1 hit
MF_01349 PanCY, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003136 Cytidylate_kin
IPR011994 Cytidylate_kinase_dom
IPR027417 P-loop_NTPase
IPR003721 Pantoate_ligase
IPR024894 Pantoate_ligase/cytidylate_kin
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF02224 Cytidylate_kin, 1 hit
PF02569 Pantoate_ligase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00017 cmk, 1 hit
TIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YSZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLTTVAAL RCYLNKRRWE SRLTASEEQI LDSMTSWYQT AIGLVPTMGS
60 70 80 90 100
LHQGHLSLIE RARHENSTVI VSIFINPLQF GPNEDYGRYP RTLEQDRQLC
110 120 130 140 150
EQGGVDAIFA PSPEELGIPQ KNIQESQVTQ VIPPSVMISG LCGHSRLGHF
160 170 180 190 200
QGVATIVTKL LNLVQPDRAY FGQKDGQQLA VIKRLVADLD LPVEIVACPT
210 220 230 240 250
VREASGLACS SRNQYLTAQE KQQAAVLYRG LLQAEAAFKA GVRYSSRLRE
260 270 280 290 300
VVRQELAKVS SVLVEYIELV EPTTLMPLDK IQEEGMLAIA ARLGSTRLID
310 320 330 340 350
NTILRDRQPI IAIDGPAGAG KSTVARQVAT KLGLVYLDTG AMYRAVTWLV
360 370 380 390 400
LQQGIAIDDD CAIAELASKC KIELTPSQDL QSPVRVWIND TDVTQNIRTI
410 420 430 440 450
EVTSQVSAIA AQAAVRQALV KQQQRWGKRG GLVAEGRDIG THVFPDAEVK
460 470 480 490 500
IFLTASVGER ARRRQQDFQK QGQPEVSLEQ LEKDIAERDW KDSTRKVSPL
510 520 530
QKAADAVELQ TDGLSISDVA SQIVDYYQQR LSQW
Length:534
Mass (Da):59,177
Last modified:March 1, 2002 - v1
Checksum:i23434C86E3DFF1BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA Translation: BAB74635.1
PIRiAI2172
RefSeqiWP_010997087.1, NC_003272.1

Genome annotation databases

EnsemblBacteriaiBAB74635; BAB74635; BAB74635
KEGGiana:alr2936

Similar proteinsi

Entry informationi

Entry nameiPANCY_NOSS1
AccessioniPrimary (citable) accession number: Q8YSZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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