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Q8YSM8

- HISX1_NOSS1

UniProt

Q8YSM8 - HISX1_NOSS1

Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NADBy similarity
    Binding sitei188 – 1881NADBy similarity
    Binding sitei211 – 2111NADBy similarity
    Binding sitei234 – 2341SubstrateBy similarity
    Metal bindingi256 – 2561ZincBy similarity
    Binding sitei256 – 2561SubstrateBy similarity
    Metal bindingi259 – 2591ZincBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Active sitei324 – 3241Proton acceptorBy similarity
    Active sitei325 – 3251Proton acceptorBy similarity
    Binding sitei325 – 3251SubstrateBy similarity
    Metal bindingi358 – 3581ZincBy similarity
    Binding sitei358 – 3581SubstrateBy similarity
    Binding sitei412 – 4121SubstrateBy similarity
    Metal bindingi417 – 4171ZincBy similarity
    Binding sitei417 – 4171SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 1 (EC:1.1.1.23)
    Short name:
    HDH 1
    Gene namesi
    Name:hisD1
    Ordered Locus Names:alr3056
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Histidinol dehydrogenase 1PRO_0000135715Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.alr3056.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YSM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiERISSFH.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YSM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVLKTTDKE FSPRFQSLVS DRREATVDVS GTVRDILAHV KARGDAAVQE    50
    YTSRFDHYRP HSHHLSAAFI AEQAAKCSDE VKAALELAAE RISSFHQKQL 100
    PQDIGYTDTA GVKLGLNWVA LSQVGIYVPG GRASYPSSVL MNALPAKIAG 150
    VERIVMTVPM PHGEINPAVL AAAQVAGVTE IYSIGGAQAV GALAYGTETI 200
    TPVDKIVGPG NAYVAEAKRQ VFGTVGIDSI AGPSEILVVA DRQNNPEWIA 250
    WDLLSQAEHD PSAQSILITD SESFAQQVIA AVEQILTTLP SQKVASSSWQ 300
    NHGAVIIVRD LAESIPLLNQ LAPEHVELCV DNPQLLASQI KCAGSLFLGR 350
    YTPEAIGDYL GGPNHVLPTS RSARFASGLS VYDFLKRITY LECNQAALQK 400
    IGQSAVTLAE TEGLPAHAGS VAVRLQGLKD M 431
    Length:431
    Mass (Da):46,004
    Last modified:March 1, 2002 - v1
    Checksum:i9CFDBD626377F5D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB74755.1.
    PIRiAI2187.
    RefSeqiNP_487096.1. NC_003272.1.
    WP_010997207.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB74755; BAB74755; BAB74755.
    GeneIDi1106654.
    KEGGiana:alr3056.
    PATRICi22776446. VBINosSp37423_3683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB74755.1 .
    PIRi AI2187.
    RefSeqi NP_487096.1. NC_003272.1.
    WP_010997207.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YSM8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr3056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB74755 ; BAB74755 ; BAB74755 .
    GeneIDi 1106654.
    KEGGi ana:alr3056.
    PATRICi 22776446. VBINosSp37423_3683.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi ERISSFH.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiHISX1_NOSS1
    AccessioniPrimary (citable) accession number: Q8YSM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3