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Q8YSM8

- HISX1_NOSS1

UniProt

Q8YSM8 - HISX1_NOSS1

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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADBy similarity
Binding sitei188 – 1881NADBy similarity
Binding sitei211 – 2111NADBy similarity
Binding sitei234 – 2341SubstrateBy similarity
Metal bindingi256 – 2561ZincBy similarity
Binding sitei256 – 2561SubstrateBy similarity
Metal bindingi259 – 2591ZincBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Active sitei324 – 3241Proton acceptorBy similarity
Active sitei325 – 3251Proton acceptorBy similarity
Binding sitei325 – 3251SubstrateBy similarity
Metal bindingi358 – 3581ZincBy similarity
Binding sitei358 – 3581SubstrateBy similarity
Binding sitei412 – 4121SubstrateBy similarity
Metal bindingi417 – 4171ZincBy similarity
Binding sitei417 – 4171SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Ordered Locus Names:alr3056
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenase 1PRO_0000135715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.alr3056.

Structurei

3D structure databases

ProteinModelPortaliQ8YSM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiERISSFH.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YSM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVLKTTDKE FSPRFQSLVS DRREATVDVS GTVRDILAHV KARGDAAVQE
60 70 80 90 100
YTSRFDHYRP HSHHLSAAFI AEQAAKCSDE VKAALELAAE RISSFHQKQL
110 120 130 140 150
PQDIGYTDTA GVKLGLNWVA LSQVGIYVPG GRASYPSSVL MNALPAKIAG
160 170 180 190 200
VERIVMTVPM PHGEINPAVL AAAQVAGVTE IYSIGGAQAV GALAYGTETI
210 220 230 240 250
TPVDKIVGPG NAYVAEAKRQ VFGTVGIDSI AGPSEILVVA DRQNNPEWIA
260 270 280 290 300
WDLLSQAEHD PSAQSILITD SESFAQQVIA AVEQILTTLP SQKVASSSWQ
310 320 330 340 350
NHGAVIIVRD LAESIPLLNQ LAPEHVELCV DNPQLLASQI KCAGSLFLGR
360 370 380 390 400
YTPEAIGDYL GGPNHVLPTS RSARFASGLS VYDFLKRITY LECNQAALQK
410 420 430
IGQSAVTLAE TEGLPAHAGS VAVRLQGLKD M
Length:431
Mass (Da):46,004
Last modified:March 1, 2002 - v1
Checksum:i9CFDBD626377F5D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB74755.1.
PIRiAI2187.
RefSeqiNP_487096.1. NC_003272.1.
WP_010997207.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB74755; BAB74755; BAB74755.
GeneIDi1106654.
KEGGiana:alr3056.
PATRICi22776446. VBINosSp37423_3683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB74755.1 .
PIRi AI2187.
RefSeqi NP_487096.1. NC_003272.1.
WP_010997207.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YSM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr3056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB74755 ; BAB74755 ; BAB74755 .
GeneIDi 1106654.
KEGGi ana:alr3056.
PATRICi 22776446. VBINosSp37423_3683.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi ERISSFH.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiHISX1_NOSS1
AccessioniPrimary (citable) accession number: Q8YSM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3