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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase 2 (hisD2), Histidinol dehydrogenase 1 (hisD1)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127NADBy similarity1
Binding sitei188NADBy similarity1
Binding sitei211NADBy similarity1
Binding sitei234SubstrateBy similarity1
Metal bindingi256ZincBy similarity1
Binding sitei256SubstrateBy similarity1
Metal bindingi259ZincBy similarity1
Binding sitei259SubstrateBy similarity1
Active sitei324Proton acceptorBy similarity1
Active sitei325Proton acceptorBy similarity1
Binding sitei325SubstrateBy similarity1
Metal bindingi358ZincBy similarity1
Binding sitei358SubstrateBy similarity1
Binding sitei412SubstrateBy similarity1
Metal bindingi417ZincBy similarity1
Binding sitei417SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Ordered Locus Names:alr3056
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357151 – 431Histidinol dehydrogenase 1Add BLAST431

Interactioni

Protein-protein interaction databases

STRINGi103690.alr3056.

Structurei

3D structure databases

ProteinModelPortaliQ8YSM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105CEK. Bacteria.
COG0141. LUCA.
HOGENOMiHOG000243914.
KOiK00013.
OMAiERISSFH.
OrthoDBiPOG091H03YX.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YSM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLKTTDKE FSPRFQSLVS DRREATVDVS GTVRDILAHV KARGDAAVQE
60 70 80 90 100
YTSRFDHYRP HSHHLSAAFI AEQAAKCSDE VKAALELAAE RISSFHQKQL
110 120 130 140 150
PQDIGYTDTA GVKLGLNWVA LSQVGIYVPG GRASYPSSVL MNALPAKIAG
160 170 180 190 200
VERIVMTVPM PHGEINPAVL AAAQVAGVTE IYSIGGAQAV GALAYGTETI
210 220 230 240 250
TPVDKIVGPG NAYVAEAKRQ VFGTVGIDSI AGPSEILVVA DRQNNPEWIA
260 270 280 290 300
WDLLSQAEHD PSAQSILITD SESFAQQVIA AVEQILTTLP SQKVASSSWQ
310 320 330 340 350
NHGAVIIVRD LAESIPLLNQ LAPEHVELCV DNPQLLASQI KCAGSLFLGR
360 370 380 390 400
YTPEAIGDYL GGPNHVLPTS RSARFASGLS VYDFLKRITY LECNQAALQK
410 420 430
IGQSAVTLAE TEGLPAHAGS VAVRLQGLKD M
Length:431
Mass (Da):46,004
Last modified:March 1, 2002 - v1
Checksum:i9CFDBD626377F5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB74755.1.
PIRiAI2187.
RefSeqiWP_010997207.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB74755; BAB74755; BAB74755.
KEGGiana:alr3056.
PATRICi22776446. VBINosSp37423_3683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB74755.1.
PIRiAI2187.
RefSeqiWP_010997207.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YSM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr3056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB74755; BAB74755; BAB74755.
KEGGiana:alr3056.
PATRICi22776446. VBINosSp37423_3683.

Phylogenomic databases

eggNOGiENOG4105CEK. Bacteria.
COG0141. LUCA.
HOGENOMiHOG000243914.
KOiK00013.
OMAiERISSFH.
OrthoDBiPOG091H03YX.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISX1_NOSS1
AccessioniPrimary (citable) accession number: Q8YSM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.