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Q8YSK6

- DEF1_NOSS1

UniProt

Q8YSK6 - DEF1_NOSS1

Protein

Peptide deformylase 1

Gene

def1

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi107 – 1071IronUniRule annotation
    Metal bindingi149 – 1491IronUniRule annotation
    Active sitei150 – 1501UniRule annotation
    Metal bindingi153 – 1531IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 1UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 1UniRule annotation
    Gene namesi
    Name:def1UniRule annotation
    Ordered Locus Names:alr3079
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Peptide deformylase 1PRO_0000082730Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.alr3079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YSK6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiDCEPDNA.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YSK6-1 [UniParc]FASTAAdd to Basket

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    MPSEIAVEKK KLKNPPLQLH YLGDRVLRQP AKRITKVDDE TRQLIRDMLQ    50
    TMYSSDGIGL AAPQVGINKQ LIVIDCEPDN PANPPLILIN PTIKQVSREI 100
    CSAQEGCLSI PGVYMDVKRP EVVEVAYKDE NGRPQTLKAT DLLGRCIQHE 150
    MDHLNGVVFV DRVDNSLTLA QELSKNGFSY QAVKPVA 187
    Length:187
    Mass (Da):20,827
    Last modified:March 1, 2002 - v1
    Checksum:iFB06469799C55CA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB74778.1.
    PIRiAH2190.
    RefSeqiNP_487119.1. NC_003272.1.
    WP_010997230.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB74778; BAB74778; BAB74778.
    GeneIDi1106677.
    KEGGiana:alr3079.
    PATRICi22776496. VBINosSp37423_3708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB74778.1 .
    PIRi AH2190.
    RefSeqi NP_487119.1. NC_003272.1.
    WP_010997230.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YSK6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr3079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB74778 ; BAB74778 ; BAB74778 .
    GeneIDi 1106677.
    KEGGi ana:alr3079.
    PATRICi 22776496. VBINosSp37423_3708.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi DCEPDNA.
    OrthoDBi EOG664CMF.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiDEF1_NOSS1
    AccessioniPrimary (citable) accession number: Q8YSK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3