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Q8YSJ2

- PUR9_NOSS1

UniProt

Q8YSJ2 - PUR9_NOSS1

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:all3093
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Bifunctional purine biosynthesis protein PurHPRO_0000192067Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all3093.

Structurei

3D structure databases

ProteinModelPortaliQ8YSJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCNLKGIS.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YSJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLALLSVS NKTGLIDLAR RLVEEFEFDL ISSGGTAQAL KDAGLPVTKV
60 70 80 90 100
ADYTGSPEIL GGRVKTLHPR IHGGILARRD VASDLTDLEN NQIRPIDLVV
110 120 130 140 150
VNLYPFESTI AKPGVTLAEA VEQIDIGGPA MLRASSKNFA HLTVLCDPAQ
160 170 180 190 200
YDEYLQELRQ NNGVASLEFR QKAALKGFLH TASYDSAIAS YLSGTQQHTL
210 220 230 240 250
SGTELQSLRY GENPHQPAAW YQTGTTPTGW TAAEKLQGKE LSYNNLVDLE
260 270 280 290 300
AARRIIAEFT DTPAATIIKH TNPCGTALAD TIVEAYQKAF NADATSAFGG
310 320 330 340 350
IVALNRPIDA ATASELTKTF LECVIAPDCD AEAQKILSKK SNVRVLTLAD
360 370 380 390 400
LSTGPKTLVK QIAGGFLVQA ADDIAADTSQ WQVVTERQPT PDELAELLFA
410 420 430 440 450
WKVCKHVKSN AIVVTSDRTT LGVGAGQMNR IGSTKIALEQ AGDKAKGAIL
460 470 480 490 500
ASDGFFPFDD TVRTAAAAGI SAIVQPGGSL RDQDSVKAAN ELGLLMVLTG

VRHFLH
Length:506
Mass (Da):54,035
Last modified:March 1, 2002 - v1
Checksum:iB6F3187B7F026D33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB74792.1.
PIRiAF2192.
RefSeqiNP_487133.1. NC_003272.1.
WP_010997244.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB74792; BAB74792; BAB74792.
GeneIDi1106691.
KEGGiana:all3093.
PATRICi22776530. VBINosSp37423_3725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB74792.1 .
PIRi AF2192.
RefSeqi NP_487133.1. NC_003272.1.
WP_010997244.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YSJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all3093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB74792 ; BAB74792 ; BAB74792 .
GeneIDi 1106691.
KEGGi ana:all3093.
PATRICi 22776530. VBINosSp37423_3725.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CNLKGIS.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiPUR9_NOSS1
AccessioniPrimary (citable) accession number: Q8YSJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3