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Q8YS28 (HIS2_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine biosynthesis bifunctional protein HisIE

Including the following 2 domains:

  1. Phosphoribosyl-AMP cyclohydrolase
    Short name=PRA-CH
    EC=3.5.4.19
  2. Phosphoribosyl-ATP pyrophosphatase
    Short name=PRA-PH
    EC=3.6.1.31
Gene names
Name:hisI
Synonyms:hisIE
Ordered Locus Names:all3263
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01019

1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01019

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01019

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Subcellular location

Cytoplasm By similarity HAMAP MF_01019.

Sequence similarities

In the N-terminal section; belongs to the PRA-CH family.

In the C-terminal section; belongs to the PRA-PH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Histidine biosynthesis bifunctional protein HisIE HAMAP MF_01019
PRO_0000136400

Regions

Region1 – 127127Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01019
Region128 – 21689Phosphoribosyl-ATP pyrophosphohydrolase HAMAP MF_01019

Sequences

Sequence LengthMass (Da)Tools
Q8YS28 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: BE7BA67DB85F2BDC

FASTA21624,397
        10         20         30         40         50         60 
MSFIDSLSPQ NVIPVEEIRY DERGLVPAIV QDYLDGTVLM MAWMNRESLQ KTLDTGETWF 

        70         80         90        100        110        120 
WSRSRQEFWH KGGTSGHTQK VQSIRYDCDS DALLVGVEQI GDIACHTGER SCFHQVEGKI 

       130        140        150        160        170        180 
VAPPGDTLSQ VFQVICDRRN HPTESSYTSK LFAGGDNKIL KKIGEESAEV VMACKDDDQE 

       190        200        210 
AIAGEVADLL YHTLVALAHH QVDIKAVYRK LQERRR 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB74962.1.
PIRAH2213.
RefSeqNP_487303.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YS28.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8YS28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1106861.
GenomeReviewsGene locus all3263 in contig BA000019_GR.
KEGGana:all3263.
NMPDRfig|103690.1.peg.3570.
PATRIC22776900. VBINosSp37423_3908.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0139.
HOGENOMHBG294308.
OMAVMACKDD.
PhylomeDBQ8YS28.
ProtClustDBPRK02759.

Enzyme and pathway databases

BioCycNSP103690:ALL3263-MONOMER.

Family and domain databases

HAMAPMF_01019. HisIE.
[Tree]
InterProIPR023019. His_synth_HisIE.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase.
[Graphical view]
KOK11755.
PfamPF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03188. Histidine_hisI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS2_NOSS1
AccessionPrimary (citable) accession number: Q8YS28
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families