Q8YRZ2 (ACSF3_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 3
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase 3
EC=1.14.13.81

Gene names

Name:	acsF3
Ordered Locus Names:	alr3300

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840
Catalytic activity	Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840
Cofactor	Iron By similarity. HAMAP MF_01840
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840
Sequence similarities	Belongs to the AcsF family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	Iron Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 3 HAMAP MF_01840		PRO_0000217528

Sequences

	Sequence		Length	Mass (Da)
	Q8YRZ2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 126C5F1C4C4984F7	FASTA	358	42,298
	10 20 30 40 50 60 MVDSLKKPGF EEIRPGVKVP AKETLLTPRF YTTDFDEMAR MDISVNEDEL LAILEEFRTD 70 80 90 100 110 120 YNRHHFVRDA EFEKSWDHID GDTRRLFVEF LERSCTAEFS GFLLYKELGR RLKDKSPVLA 130 140 150 160 170 180 ECFNLMSRDE ARHAGFLNKA MSDFNLSLDL GFLTKSRNYT FFKPKFIFYA TYLSEKIGYW 190 200 210 220 230 240 RYITIYRHLE AHPEDRIYPI FRFFENWCQD ENRHGDFFDA IMKSQPQMLN DWKAKLWSRF 250 260 270 280 290 300 FLLSVFATMY LNDIQRKDFY ATIGLDARDY DIYVIKKTNE TAGRVFPIIL DVDSPEFYER 310 320 330 340 350 LDICVENSEK LSAIASSNTP KFLQFFQKLP VLASTGWQLL RLYLMKPIDA VSAQGAAR

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB74999.1.
PIR	AE2218.
RefSeq	NP_487340.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YRZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YRZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1106898.
GenomeReviews	Gene locus alr3300 in contig BA000019_GR.
KEGG	ana:alr3300.
NMPDR	fig|103690.1.peg.3607.
PATRIC	22776972. VBINosSp37423_3944.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG10633.
HOGENOM	HBG284843.
OMA	HGDFFDA.
PhylomeDB	Q8YRZ2.
ProtClustDB	PRK13654.
Enzyme and pathway databases
BioCyc	NSP103690:ALR3300-MONOMER.
Family and domain databases
HAMAP	MF_01840. AcsF. [Tree]
InterPro	IPR008434. AcsF. IPR009078. Ferritin/RR-like. IPR003251. Rubrerythrin. [Graphical view]
KO	K04035.
Pfam	PF02915. Rubrerythrin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMs	TIGR02029. AcsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACSF3_NOSS1

Accession

Primary (citable) accession number: Q8YRZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program