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Q8YRP3

- SPEA_NOSS1

UniProt

Q8YRP3 - SPEA_NOSS1

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:all3401
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679Biosynthetic arginine decarboxylasePRO_0000149956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi103690.all3401.

Structurei

3D structure databases

ProteinModelPortaliQ8YRP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni331 – 34111Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiDSEDMVE.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YRP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHRGQEEMG VESTATSDEV VKVPANGNKL EGKNHKQKKL LPTNTPGDVS
60 70 80 90 100
RVWKIEDSEA LYRIEGWGQP YFSINAAGHV TVSPKGDRGG SLDLFELVNA
110 120 130 140 150
LKQRSLGLPL LIRFSDILED RIERLNACFA KAIARYNYPG VYRGVFPVKC
160 170 180 190 200
NQQRHLIEDL VRFGRPHQFG LEAGSKPELM IALALLDTPG SLLICNGYKD
210 220 230 240 250
REYVETAMLS QRLGQTPIIV LEQVEEVDLV IAASHQLGIK PILGVRAKLS
260 270 280 290 300
TQGMGRWGTS TGDRAKFGLT IPEIIQAVDK LRDADLLDSL QLMHFHIGSQ
310 320 330 340 350
ISAINVIKDA IQEASRIYVE LASLGANMKY LDVGGGLGVD YDGSQTNFYA
360 370 380 390 400
SKNYNMQNYA NDIVAELKDT CAEKQIPVPT LISESGRAIA SHQSVLIFDV
410 420 430 440 450
LSTSDVPRDN PEPPKEGESP VINYLWETYQ SINKENYQEF YHDATQFKEE
460 470 480 490 500
AISRFNLGIL RLRERAKAER LYWACCQKIL DIIRQHDYVP DELEDLEKIM
510 520 530 540 550
ASIYYINLSV FQSAPDCWAI DQLFPIMPIH RLDEEPTQRG ILADLTCDSD
560 570 580 590 600
GKIDRFIDLR DVKSVLELHP FQPGEPYYMG MFLNGAYQEI MGNLHNLFGD
610 620 630 640 650
TNAVHIQLTP KGYQIEHVVK GDTMSEVVSY VQYDSEDMVE NIRQRCERAL
660 670
EEKRITLAES QRLLQTYEQS LRRYTYLNS
Length:679
Mass (Da):76,821
Last modified:March 1, 2002 - v1
Checksum:i7A0AABEBB9FC6482
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB75100.1.
PIRiAB2231.
RefSeqiNP_487441.1. NC_003272.1.
WP_010997551.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB75100; BAB75100; BAB75100.
GeneIDi1106999.
KEGGiana:all3401.
PATRICi22777190. VBINosSp37423_4052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB75100.1 .
PIRi AB2231.
RefSeqi NP_487441.1. NC_003272.1.
WP_010997551.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YRP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all3401.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB75100 ; BAB75100 ; BAB75100 .
GeneIDi 1106999.
KEGGi ana:all3401.
PATRICi 22777190. VBINosSp37423_4052.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi DSEDMVE.
OrthoDBi EOG676Z0R.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiSPEA_NOSS1
AccessioniPrimary (citable) accession number: Q8YRP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3