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Q8YRP3

- SPEA_NOSS1

UniProt

Q8YRP3 - SPEA_NOSS1

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Protein

Biosynthetic arginine decarboxylase

Gene
speA, all3401
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:all3401
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679Biosynthetic arginine decarboxylaseUniRule annotationPRO_0000149956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi103690.all3401.

Structurei

3D structure databases

ProteinModelPortaliQ8YRP3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni331 – 34111Substrate-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiDSEDMVE.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YRP3-1 [UniParc]FASTAAdd to Basket

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MKHRGQEEMG VESTATSDEV VKVPANGNKL EGKNHKQKKL LPTNTPGDVS    50
RVWKIEDSEA LYRIEGWGQP YFSINAAGHV TVSPKGDRGG SLDLFELVNA 100
LKQRSLGLPL LIRFSDILED RIERLNACFA KAIARYNYPG VYRGVFPVKC 150
NQQRHLIEDL VRFGRPHQFG LEAGSKPELM IALALLDTPG SLLICNGYKD 200
REYVETAMLS QRLGQTPIIV LEQVEEVDLV IAASHQLGIK PILGVRAKLS 250
TQGMGRWGTS TGDRAKFGLT IPEIIQAVDK LRDADLLDSL QLMHFHIGSQ 300
ISAINVIKDA IQEASRIYVE LASLGANMKY LDVGGGLGVD YDGSQTNFYA 350
SKNYNMQNYA NDIVAELKDT CAEKQIPVPT LISESGRAIA SHQSVLIFDV 400
LSTSDVPRDN PEPPKEGESP VINYLWETYQ SINKENYQEF YHDATQFKEE 450
AISRFNLGIL RLRERAKAER LYWACCQKIL DIIRQHDYVP DELEDLEKIM 500
ASIYYINLSV FQSAPDCWAI DQLFPIMPIH RLDEEPTQRG ILADLTCDSD 550
GKIDRFIDLR DVKSVLELHP FQPGEPYYMG MFLNGAYQEI MGNLHNLFGD 600
TNAVHIQLTP KGYQIEHVVK GDTMSEVVSY VQYDSEDMVE NIRQRCERAL 650
EEKRITLAES QRLLQTYEQS LRRYTYLNS 679
Length:679
Mass (Da):76,821
Last modified:March 1, 2002 - v1
Checksum:i7A0AABEBB9FC6482
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB75100.1.
PIRiAB2231.
RefSeqiNP_487441.1. NC_003272.1.
WP_010997551.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB75100; BAB75100; BAB75100.
GeneIDi1106999.
KEGGiana:all3401.
PATRICi22777190. VBINosSp37423_4052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB75100.1 .
PIRi AB2231.
RefSeqi NP_487441.1. NC_003272.1.
WP_010997551.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YRP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all3401.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB75100 ; BAB75100 ; BAB75100 .
GeneIDi 1106999.
KEGGi ana:all3401.
PATRICi 22777190. VBINosSp37423_4052.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi DSEDMVE.
OrthoDBi EOG676Z0R.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiSPEA_NOSS1
AccessioniPrimary (citable) accession number: Q8YRP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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