Reviewed, UniProtKB/Swiss-Prot Q8YRB1 (ARGC1_ANASP)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase 1
      Short name=AGPR 1
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase 1
      Short name=NAGSA dehydrogenase 1

Gene names

Name:	argC1
Ordered Locus Names:	alr3537

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
Caution	Ser-155 is present instead of the conserved Cys which is expected to be an active site residue.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	N-acetyl-gamma-glutamyl-phosphate reductase 1 HAMAP MF_00150		PRO_0000112374

Sequences

	Sequence		Length	Mass (Da)
	Q8YRB1-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 09C0AF871242635D	FASTA	352	38,239
	10 20 30 40 50 60 MGNFGRVPVG IVGASGYGGV QLVRLLMDHP EIELVYLGGE SSVGKSFASL YPHLAHAVKL 70 80 90 100 110 120 SIEEVDPEVI ARRCEVVFLS MPNGLACQIV PTLLEKGCKV LDLSADYRFR NLTTYTTWYG 130 140 150 160 170 180 VERSDRTTAD TAIYGLPELY RDRISEAQLV GCPGSYPTAS LLALSPLLKQ GLIVPETAIV 190 200 210 220 230 240 DAKSGTSGGG REAKTYLLLA EADNSLAPYS VVRHRHTPEI EQICSDLAGH EVTVQFTPHL 250 260 270 280 290 300 VPIVRGILAT VYATLRDPGL VGDDLTTIYT AFYRNSPWVK VCESGIYPQT KWAAGSNLCY 310 320 330 340 350 IGVEVDPRTG RVIVMSVIDN LIKGQAGQAI QCLNIMMGWD ETLGLPKMGF YP

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB75236.1.
PIR	AB2248.
RefSeq	NP_487577.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YRB1.
Genome annotation databases
GeneID	1107135.
GenomeReviews	Gene locus alr3537 in contig BA000019_GR.
KEGG	ana:alr3537.
NMPDR	fig|103690.1.peg.3844.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YRB1.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	NSP103690:ALR3537-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC1_ANASP

Accession

Primary (citable) accession number: Q8YRB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)