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Protein

Methylthioribose-1-phosphate isomerase

Gene

mtnA

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (mtnA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Acireductone dioxygenase (mtnD)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88SubstrateUniRule annotation1
Sitei158Transition state stabilizerUniRule annotation1
Binding sitei197SubstrateUniRule annotation1
Active sitei238Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Name:mtnAUniRule annotation
Ordered Locus Names:all3566
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003571351 – 347Methylthioribose-1-phosphate isomeraseAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi103690.all3566.

Structurei

3D structure databases

ProteinModelPortaliQ8YR82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 47Substrate bindingUniRule annotation3
Regioni248 – 249Substrate bindingUniRule annotation2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
HOGENOMiHOG000224730.
KOiK08963.
OMAiFYNPAFD.
OrthoDBiPOG091H022L.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YR82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYPVIWQNN CVLLIDQTRL PNEYAVVEIH RSEDMARAIQ TMIVRGAPAI
60 70 80 90 100
GVAAAYGMYL GAREIETGER QEFLQELEKV AQLLRATRPT AVNLFWAISR
110 120 130 140 150
MQKTAYKTLG TVAQIKENLL QTAQAINAED LQTCQAIGDN GLAILPKTPE
160 170 180 190 200
KLTLLTHCNA GALATAGYGT ALGVVRSAWR EGRLERLFAD ETRPRLQGAK
210 220 230 240 250
LTTWECVQEG IPVTLITDNM AAHCMKQGLI HAVVVGADRI AANGDAANKI
260 270 280 290 300
GTYSLAIVAK AHNVPFFVAA PVSTIDFELA DGSQIPIEER NPVEIYQVGD
310 320 330 340
TTLTPPGVKF YNPAFDVTPA ELITAIITEN GAFAPHVLTK SSQQAVV
Length:347
Mass (Da):37,633
Last modified:March 1, 2002 - v1
Checksum:i880BBCAC19FE0FA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB75265.1.
PIRiAG2251.
RefSeqiWP_010997716.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB75265; BAB75265; BAB75265.
KEGGiana:all3566.
PATRICi22777562. VBINosSp37423_4236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB75265.1.
PIRiAG2251.
RefSeqiWP_010997716.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YR82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.all3566.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB75265; BAB75265; BAB75265.
KEGGiana:all3566.
PATRICi22777562. VBINosSp37423_4236.

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
HOGENOMiHOG000224730.
KOiK08963.
OMAiFYNPAFD.
OrthoDBiPOG091H022L.

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTNA_NOSS1
AccessioniPrimary (citable) accession number: Q8YR82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 1, 2002
Last modified: October 5, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.