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Protein

Adaptive-response sensory-kinase SasA

Gene

sasA

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.UniRule annotation

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Biological rhythms, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adaptive-response sensory-kinase SasAUniRule annotation (EC:2.7.13.3)
Gene namesi
Name:sasAUniRule annotation
Ordered Locus Names:all3600
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Adaptive-response sensory-kinase SasAPRO_0000074867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphohistidine; by autocatalysisUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers.UniRule annotation

Protein-protein interaction databases

STRINGi103690.all3600.

Structurei

3D structure databases

ProteinModelPortaliQ8YR50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 400226Histidine kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000233315.
KOiK08479.
OMAiAHYGQIW.
OrthoDBiPOG091H0M9D.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_01837. Kinase_SasA. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR011649. KaiB_domain.
IPR023527. Kinase_SasA.
IPR004358. Sig_transdc_His_kin-like_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF07689. KaiB. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YR50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKHDSMQVS QDQPIYSEAP LQLLLFVDGR PKSKQQVQRI RAYLKDLQAE
60 70 80 90 100
YNFELQIIDV GQQPYLAEHF KLVATPALIK IHPEPRQILA GSNIITQLKN
110 120 130 140 150
LWPRWQAAAD TYAKLQEDLQ ERVDDNGRVA QPQSTINSVA VSAELLRLSD
160 170 180 190 200
EIFNLKQEKE KLLEQLQFKD RVIAMLVHDL RNPLTAAAIA IETLQSNYNP
210 220 230 240 250
DIGQFQRLKP ALVVNLLRQA RTQAKTIDKM IADLLQVGRG TDTELIIIPQ
260 270 280 290 300
KTEIGLLCLE VLGELRDRYT TKAQKVETDI PQDLPCVYAD PERIRQVLIN
310 320 330 340 350
LLDNAIKYTP EGGTISIAGL HRTTQKVQFS IGDTGPGIPS DNRERIFENH
360 370 380 390 400
YRLERDEAKE GYGIGLSLCQ RIIRAHYGQI WVDSNPHGGA WFHFTLPVYP

S
Length:401
Mass (Da):45,565
Last modified:March 1, 2002 - v1
Checksum:i884243505413FDDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB75299.1.
PIRiAI2255.

Genome annotation databases

EnsemblBacteriaiBAB75299; BAB75299; BAB75299.
KEGGiana:all3600.
PATRICi22777638. VBINosSp37423_4274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB75299.1.
PIRiAI2255.

3D structure databases

ProteinModelPortaliQ8YR50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.all3600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB75299; BAB75299; BAB75299.
KEGGiana:all3600.
PATRICi22777638. VBINosSp37423_4274.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000233315.
KOiK08479.
OMAiAHYGQIW.
OrthoDBiPOG091H0M9D.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_01837. Kinase_SasA. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR011649. KaiB_domain.
IPR023527. Kinase_SasA.
IPR004358. Sig_transdc_His_kin-like_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF07689. KaiB. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSASA_NOSS1
AccessioniPrimary (citable) accession number: Q8YR50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.