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Protein

Adaptive-response sensory-kinase SasA

Gene

sasA

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.UniRule annotation

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processBiological rhythms, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adaptive-response sensory-kinase SasAUniRule annotation (EC:2.7.13.3)
Gene namesi
Name:sasAUniRule annotation
Ordered Locus Names:all3600
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000748671 – 401Adaptive-response sensory-kinase SasAAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178Phosphohistidine; by autocatalysisUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8YR50

Interactioni

Subunit structurei

Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers.UniRule annotation

Protein-protein interaction databases

STRINGi103690.all3600

Structurei

3D structure databases

ProteinModelPortaliQ8YR50
SMRiQ8YR50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 400Histidine kinaseUniRule annotationAdd BLAST226

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
HOGENOMiHOG000233315
KOiK08479
OMAiHFTLPVY
OrthoDBiPOG091H0M9D

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
cd02978 KaiB_like, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_01837 Kinase_SasA, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR011649 KaiB_domain
IPR023527 Kinase_SasA
IPR004358 Sig_transdc_His_kin-like_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF07689 KaiB, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM01248 KaiB, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF52833 SSF52833, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YR50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKHDSMQVS QDQPIYSEAP LQLLLFVDGR PKSKQQVQRI RAYLKDLQAE
60 70 80 90 100
YNFELQIIDV GQQPYLAEHF KLVATPALIK IHPEPRQILA GSNIITQLKN
110 120 130 140 150
LWPRWQAAAD TYAKLQEDLQ ERVDDNGRVA QPQSTINSVA VSAELLRLSD
160 170 180 190 200
EIFNLKQEKE KLLEQLQFKD RVIAMLVHDL RNPLTAAAIA IETLQSNYNP
210 220 230 240 250
DIGQFQRLKP ALVVNLLRQA RTQAKTIDKM IADLLQVGRG TDTELIIIPQ
260 270 280 290 300
KTEIGLLCLE VLGELRDRYT TKAQKVETDI PQDLPCVYAD PERIRQVLIN
310 320 330 340 350
LLDNAIKYTP EGGTISIAGL HRTTQKVQFS IGDTGPGIPS DNRERIFENH
360 370 380 390 400
YRLERDEAKE GYGIGLSLCQ RIIRAHYGQI WVDSNPHGGA WFHFTLPVYP

S
Length:401
Mass (Da):45,565
Last modified:March 1, 2002 - v1
Checksum:i884243505413FDDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA Translation: BAB75299.1
PIRiAI2255

Genome annotation databases

EnsemblBacteriaiBAB75299; BAB75299; BAB75299
KEGGiana:all3600

Similar proteinsi

Entry informationi

Entry nameiSASA_NOSS1
AccessioniPrimary (citable) accession number: Q8YR50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health