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Q8YQR8 (HEMH_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:alr3751
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Ferrochelatase HAMAP MF_00323
PRO_0000175100

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YQR8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 9B6451AC90C60D68

FASTA38844,305
        10         20         30         40         50         60 
MGRVGVLLLN LGGPDKLEDV APFLFNLFSD PEIIRLPFRW LQKPLAWFIA SRRTKTSQEN 

        70         80         90        100        110        120 
YKQIGGGSPL RRITEAQGEA LKEQLHYLGQ EANIYVGMRY WHPYTEEAIA LLTQDNLDNL 

       130        140        150        160        170        180 
VILPLYPQFS ISTSGSSFRL LERLWQEDPK LQRLEYTVIP SWYKEPGYLQ AMAELIRQEI 

       190        200        210        220        230        240 
EQFPHPDQVH VFFSAHGVPK SYVEEAGDPY QQEIEECTAL IMQTLNRPNP HTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE DALKELGAQG VKDLVVVPIS FVSEHIETLQ EIDIEYREIA EEAGIHNFRR 

       310        320        330        340        350        360 
VPAPNTHPVF IRALADLVID ALNKPSFKLS QAAQIKKMVK MYPPESWEWG MTSSAEVWNG 

       370        380 
RIAMLGFIAL IIELVTGQGL LHMIGLLQ

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000019 Genomic DNA. Translation: BAB75450.1.
PIRAH2274.
RefSeqNP_487791.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YQR8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8YQR8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1107349.
GenomeReviewsGene locus alr3751 in contig BA000019_GR.
KEGGana:alr3751.
NMPDRfig|103690.1.peg.4058.
PATRIC22777972. VBINosSp37423_4440.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ8YQR8.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycNSP103690:ALR3751-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_NOSS1
AccessionPrimary (citable) accession number: Q8YQR8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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