Reviewed, UniProtKB/Swiss-Prot Q8YQE6 (ARLY_ANASP)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	alr3887

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137732

Sequences

	Sequence		Length	Mass (Da)
	Q8YQE6-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 29F679B11D618627	FASTA	461	51,726
	10 20 30 40 50 60 MTEKQTWSQR FESALHPAIA LFNASISFDI ELIEYDLTGS QAHAQMLAHT GIISPAEGEQ 70 80 90 100 110 120 LVAGLEQIRE EYRQGKFQPG IDAEDVHFAV ERRLTEIVGD VGKKLHTARS RNDQVGTDTR 130 140 150 160 170 180 LYLRDQILQI KTQLREFQRV LLDIAEKNVE TLIPGYTHLQ RAQPVSLAHH LLAYFQMAQR 190 200 210 220 230 240 DWERLGDVYR RVNISPLGCG ALAGTTFPID RHYTAELLQF ERIYENSLDG VSDRDFAIEF 250 260 270 280 290 300 LCAASLIMVH LSRLSEEIIL WASEEFRFVI LKDSCATGSS IMPQKKNPDV PELVRGKTGR 310 320 330 340 350 360 VFGHLQAMLV IMKGLPLAYN KDLQEDKEGL FDSVNTVKAC LEAMTILLQE GLEFRTQRLA 370 380 390 400 410 420 EAVTQDFSNA TDVADYLAAR GVPFREAYNI VGKVVKTSIA AGKLLKDLTL EEWQQIHPKF 430 440 450 460 ADDIYEAISP RQVVAARNSY GGTGFAQVSK AVSAARKEIG E

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB75586.1.
PIR	AH2291.
RefSeq	NP_487927.1.
3D structure databases
HSSP	HSSP built from PDB template 1DCN based on UniProtKB P24058.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YQE6.
Genome annotation databases
GeneID	1107485.
GenomeReviews	Gene locus alr3887 in contig BA000019_GR.
KEGG	ana:alr3887.
NMPDR	fig|103690.1.peg.4194.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YQE6.
OMA	MAEDLIF.
Enzyme and pathway databases
BioCyc	NSP103690:ALR3887-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ANASP

Accession

Primary (citable) accession number: Q8YQE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)