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Q8YQC4 (DCUP_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:all3909
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm Probable HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000187579

Regions

Region28 – 325Substrate binding By similarity

Sites

Binding site471Substrate By similarity
Binding site781Substrate By similarity
Binding site1551Substrate By similarity
Binding site2101Substrate By similarity
Binding site3251Substrate By similarity
Site781Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YQC4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6E322962F4C63746

FASTA35038,820
        10         20         30         40         50         60 
MGVTSTAPHL LRAARGEIVD RPPVWMMRQA GRYMKAYRDL REKYPSFRDR SEIPEVAIEV 

        70         80         90        100        110        120 
SLQPWKAFQP DGVILFSDIV TPLPGLGIEM DIAEGKGPII HAPIRTQAQI EQLRPLEPEA 

       130        140        150        160        170        180 
ALPFIKTILQ ALRQEVGNQS TVLGFVGAPW TLAAYAVEGK GSKTYSIIKN MAFSDPTILH 

       190        200        210        220        230        240 
QLLSKLADAI AIYARYQIDS GAQVVQMFDS WAGQLSPQDY DTFALPYQQR VFQQIKQTHP 

       250        260        270        280        290        300 
DTPLILLVSG SAGVLERMGQ SGADIVTVDW TVDMADARAR LGKQMKVQGN LDPGVLYASK 

       310        320        330        340        350 
QFIRDRIIDT VRKAGNWGHI LNLGHGVLPD TPEENVAFFF ETAKQLNVLV

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000019 Genomic DNA. Translation: BAB75608.1.
PIRAF2294.
RefSeqNP_487949.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YQC4.
SMRQ8YQC4. Positions 6-346.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8YQC4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1107507.
GenomeReviewsGene locus all3909 in contig BA000019_GR.
KEGGana:all3909.
NMPDRfig|103690.1.peg.4216.
PATRIC22778312. VBINosSp37423_4610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ8YQC4.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycNSP103690:ALL3909-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_NOSS1
AccessionPrimary (citable) accession number: Q8YQC4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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