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Q8YP78

- MDH_NOSS1

UniProt

Q8YP78 - MDH_NOSS1

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADUniRule annotation
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei99 – 991SubstrateUniRule annotation
Binding sitei106 – 1061NADUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Active sitei186 – 1861Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 256NADUniRule annotation
Nucleotide bindingi129 – 1313NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:alr4322
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Malate dehydrogenasePRO_0000113421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.alr4322.

Structurei

3D structure databases

ProteinModelPortaliQ8YP78.
SMRiQ8YP78. Positions 15-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLMSAGMP.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YP78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSSPDSPIL HCLPRVAIIG AGRVGSTLAQ RIAEKNLADV VLLDIVEGIP
60 70 80 90 100
QGLALDLLEA RGIELHNRQI IGTNNYADTS GSQIVVITAG FPRKPGMSRD
110 120 130 140 150
DLLRTNAKIV IEAAKQAIAY SPYAIFIVVT NPLDVMTYLA WEATGLPRNR
160 170 180 190 200
IMGMAGVLDS ARFETFIALE LGVLPADVKA MVLGSHGDLM VPLSRYATVN
210 220 230 240 250
GIPITQLLDA VTIERLVERT RNGGAEIVEL MQTGGAFFAP ASATSLMVES
260 270 280 290 300
ILLNQSRLLP VSIYLQGEYD LKDVVIGVPC RLGLNGIESV IELNLSDSER
310 320
EALHISAKSV QKNIERWRSL QNS
Length:323
Mass (Da):34,924
Last modified:August 16, 2004 - v2
Checksum:i081EEA3377A457B7
GO

Sequence cautioni

The sequence BAB76021.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB76021.1. Different initiation.
PIRiAC2346.
RefSeqiNP_488362.1. NC_003272.1.
WP_010998460.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76021; BAB76021; BAB76021.
GeneIDi1107924.
KEGGiana:alr4322.
PATRICi22779216. VBINosSp37423_5055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB76021.1 . Different initiation.
PIRi AC2346.
RefSeqi NP_488362.1. NC_003272.1.
WP_010998460.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YP78.
SMRi Q8YP78. Positions 15-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr4322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76021 ; BAB76021 ; BAB76021 .
GeneIDi 1107924.
KEGGi ana:alr4322.
PATRICi 22779216. VBINosSp37423_5055.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi LMSAGMP.
OrthoDBi EOG6091FG.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiMDH_NOSS1
AccessioniPrimary (citable) accession number: Q8YP78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 1, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3