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Q8YP73

- DAPT2_NOSS1

UniProt

Q8YP73 - DAPT2_NOSS1

Protein

LL-diaminopimelate aminotransferase 2

Gene

dapL2

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.By similarity

    Catalytic activityi

    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381Substrate; via amide nitrogenBy similarity
    Binding sitei64 – 641Pyridoxal phosphate; shared with dimeric partnerBy similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Binding sitei177 – 1771Pyridoxal phosphateBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Binding sitei205 – 2051Pyridoxal phosphateBy similarity
    Binding sitei208 – 2081Pyridoxal phosphateBy similarity
    Binding sitei236 – 2361Pyridoxal phosphateBy similarity
    Binding sitei238 – 2381Pyridoxal phosphateBy similarity
    Binding sitei247 – 2471Pyridoxal phosphateBy similarity
    Binding sitei365 – 3651SubstrateBy similarity

    GO - Molecular functioni

    1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00034; UER00466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LL-diaminopimelate aminotransferase 2 (EC:2.6.1.83)
    Short name:
    DAP-AT 2
    Short name:
    DAP-aminotransferase 2
    Short name:
    LL-DAP-aminotransferase 2
    Gene namesi
    Name:dapL2
    Ordered Locus Names:all4327
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390LL-diaminopimelate aminotransferase 2PRO_0000342210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi103690.all4327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YP73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223051.
    KOiK10206.
    OMAiMEFRRIE.
    OrthoDBiEOG6W721W.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01642. DapL_aminotrans_1.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YP73-1 [UniParc]FASTAAdd to Basket

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    MQFAKRLEKI PPYLFAEINR KREALIAKGV DIINIGVGDP DKPTPAHILQ    50
    AMREAIDDAS NHNYPPYEGT QEFREAAVEW MERRFGVMDL NPNTEVVSSI 100
    GSKEAIHNTF LAFVEAGDYT LIPDPGYPVY RTSTIFAGGE AFSMPLKAEN 150
    KFLPDLDLIP EEVARKAKML WINYPNNPTG ALATLEFFEE LVALCQQYSI 200
    LLCHDHAYSE MAYDGYKPPS VLQIPGAKDI AIEFHSLSKS YNMTGWRIGF 250
    AVGNAYAIKG LSQVKTNVDS GVFKAIQKAA IAAYATDEVE LQAVMSVYQS 300
    RRDIIVKGLQ SLGWPIEPPK ATLYVWVPVP PGYTSTEFTT LLLDKCGIVV 350
    PPGVGYGASG EGYFRVALTI SDERLHEAIQ RMQDAGIRYA 390
    Length:390
    Mass (Da):43,225
    Last modified:March 1, 2002 - v1
    Checksum:i6CFB39A6C8C32E8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB76026.1.
    PIRiAH2346.
    RefSeqiNP_488367.1. NC_003272.1.
    WP_010998465.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB76026; BAB76026; BAB76026.
    GeneIDi1107929.
    KEGGiana:all4327.
    PATRICi22779226. VBINosSp37423_5060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB76026.1 .
    PIRi AH2346.
    RefSeqi NP_488367.1. NC_003272.1.
    WP_010998465.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YP73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.all4327.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB76026 ; BAB76026 ; BAB76026 .
    GeneIDi 1107929.
    KEGGi ana:all4327.
    PATRICi 22779226. VBINosSp37423_5060.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223051.
    KOi K10206.
    OMAi MEFRRIE.
    OrthoDBi EOG6W721W.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00466 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01642. DapL_aminotrans_1.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiDAPT2_NOSS1
    AccessioniPrimary (citable) accession number: Q8YP73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3