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Protein

LL-diaminopimelate aminotransferase 2

Gene

dapL2

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase 1 (dapL1), LL-diaminopimelate aminotransferase 2 (dapL2)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei38Substrate; via amide nitrogenUniRule annotation1
Binding sitei67Pyridoxal phosphateUniRule annotation1
Binding sitei103SubstrateUniRule annotation1
Binding sitei127Pyridoxal phosphateUniRule annotation1
Binding sitei127SubstrateUniRule annotation1
Binding sitei177Pyridoxal phosphateUniRule annotation1
Binding sitei177SubstrateUniRule annotation1
Binding sitei208Pyridoxal phosphateUniRule annotation1
Binding sitei247Pyridoxal phosphateUniRule annotation1
Binding sitei365SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase 2UniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-AT 2UniRule annotation
Short name:
DAP-aminotransferase 2UniRule annotation
Short name:
LL-DAP-aminotransferase 2UniRule annotation
Gene namesi
Name:dapL2UniRule annotation
Ordered Locus Names:all4327
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422101 – 390LL-diaminopimelate aminotransferase 2Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei239N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi103690.all4327.

Structurei

3D structure databases

ProteinModelPortaliQ8YP73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 103Pyridoxal phosphate bindingUniRule annotation2
Regioni236 – 238Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223051.
KOiK10206.
OMAiLCHDHAY.
OrthoDBiPOG091H09WQ.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YP73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFAKRLEKI PPYLFAEINR KREALIAKGV DIINIGVGDP DKPTPAHILQ
60 70 80 90 100
AMREAIDDAS NHNYPPYEGT QEFREAAVEW MERRFGVMDL NPNTEVVSSI
110 120 130 140 150
GSKEAIHNTF LAFVEAGDYT LIPDPGYPVY RTSTIFAGGE AFSMPLKAEN
160 170 180 190 200
KFLPDLDLIP EEVARKAKML WINYPNNPTG ALATLEFFEE LVALCQQYSI
210 220 230 240 250
LLCHDHAYSE MAYDGYKPPS VLQIPGAKDI AIEFHSLSKS YNMTGWRIGF
260 270 280 290 300
AVGNAYAIKG LSQVKTNVDS GVFKAIQKAA IAAYATDEVE LQAVMSVYQS
310 320 330 340 350
RRDIIVKGLQ SLGWPIEPPK ATLYVWVPVP PGYTSTEFTT LLLDKCGIVV
360 370 380 390
PPGVGYGASG EGYFRVALTI SDERLHEAIQ RMQDAGIRYA
Length:390
Mass (Da):43,225
Last modified:March 1, 2002 - v1
Checksum:i6CFB39A6C8C32E8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB76026.1.
PIRiAH2346.
RefSeqiWP_010998465.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76026; BAB76026; BAB76026.
KEGGiana:all4327.
PATRICi22779226. VBINosSp37423_5060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB76026.1.
PIRiAH2346.
RefSeqiWP_010998465.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ8YP73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.all4327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB76026; BAB76026; BAB76026.
KEGGiana:all4327.
PATRICi22779226. VBINosSp37423_5060.

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223051.
KOiK10206.
OMAiLCHDHAY.
OrthoDBiPOG091H09WQ.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAPT2_NOSS1
AccessioniPrimary (citable) accession number: Q8YP73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.