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Q8YNK2

- ALF_NOSS1

UniProt

Q8YNK2 - ALF_NOSS1

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Protein
Fructose-bisphosphate aldolase
Gene
fda, all4563
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.By similarity

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Glyceraldehyde 3-phosphate By similarityBy similarity
Active sitei83 – 831Proton donor By similarityBy similarity
Metal bindingi84 – 841Zinc 1; catalytic By similarityBy similarity
Metal bindingi105 – 1051Zinc 2 By similarityBy similarity
Metal bindingi142 – 1421Zinc 2 By similarityBy similarity
Metal bindingi198 – 1981Zinc 1; catalytic By similarityBy similarity
Binding sitei199 – 1991Dihydroxyacetone phosphate; via amide nitrogen By similarityBy similarity
Metal bindingi232 – 2321Zinc 1; catalytic By similarityBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fda
Ordered Locus Names:all4563
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarityBy similarity
Chaini2 – 359358Fructose-bisphosphate aldolaseBy similarity
PRO_0000366199Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all4563.

Structurei

3D structure databases

ProteinModelPortaliQ8YNK2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni233 – 2353Dihydroxyacetone phosphate binding By similarityBy similarity
Regioni275 – 2784Dihydroxyacetone phosphate binding By similarityBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227792.
KOiK01624.
OMAiCISAITN.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006412. Fruct_bisP_Calv.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01521. FruBisAldo_II_B. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8YNK2-1 [UniParc]FASTAAdd to Basket

« Hide

MALVPLRLLL DHAAENGYGI PAFNVNNLEQ IQAILKAAAE TDSPVILQAS    50
RGARNYAGEN FLRHLILAAV ETYPEIPIVM HQDHGNAPST CYSAIKNNFT 100
SVMMDGSLEA DAKTPASFEY NVNVTREVVN VAHALGVSVE GELGCLGSLE 150
TGAGEAEDGH GFEGTLDHSQ LLTDPDEAVN FVEATQVDAL AVAIGTSHGA 200
YKFTRKPTGE ILAISRIEEI HRRLPNTHLV MHGSSSVPED LIALINEYGG 250
AIPETYGVPV EEIQKGIKSG VRKVNIDTDN RLAITAAVRE ALAKNPKEFD 300
PRHFLKPSIT YMQKVCAERY VQFGTAGNAS KIKQVSLETF AAKYAKGELN 350
AISKAAAKV 359
Length:359
Mass (Da):38,617
Last modified:March 1, 2002 - v1
Checksum:iE91D84D7591007B1
GO

Mass spectrometryi

Molecular mass is 38764±1 Da from positions 1 - 359. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB76262.1.
PIRiAC2376.
RefSeqiNP_488603.1. NC_003272.1.
WP_010998695.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76262; BAB76262; BAB76262.
GeneIDi1108164.
KEGGiana:all4563.
PATRICi22779738. VBINosSp37423_5315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB76262.1 .
PIRi AC2376.
RefSeqi NP_488603.1. NC_003272.1.
WP_010998695.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YNK2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all4563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76262 ; BAB76262 ; BAB76262 .
GeneIDi 1108164.
KEGGi ana:all4563.
PATRICi 22779738. VBINosSp37423_5315.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227792.
KOi K01624.
OMAi CISAITN.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006412. Fruct_bisP_Calv.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01521. FruBisAldo_II_B. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.
  2. Singh H., Rajaram H., Apte S.K.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 282-289, MASS SPECTROMETRY.

Entry informationi

Entry nameiALF_NOSS1
AccessioniPrimary (citable) accession number: Q8YNK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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