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Q8YNF9 (GCSP_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:all4607
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length983 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 983983Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166902

Amino acid modifications

Modified residue7311N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YNF9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 3255D178ED6CC6F0

FASTA983107,753
        10         20         30         40         50         60 
MVSYASIPQS SDEAHSTVGA SLQLDERKQD LNNFIQRHIG PSSADIQQML DVLGFSSLDD 

        70         80         90        100        110        120 
LIEKTVPSAI RLHEQLQLPE AQTEYAALAK LKQIASKNQV FRSYIGMGYY DTITPSVIGR 

       130        140        150        160        170        180 
NILENPGWYT AYTPYQPEIA QGRLEALLNF QTMIIDLTGL EIANASLLDE ATAAAEAMSM 

       190        200        210        220        230        240 
SYGVSKNKAN AYFVSHDCHP QIIDVLQTRA KPLGIEIIIG DHQTFDFDKP IFGAVLQYPA 

       250        260        270        280        290        300 
SDGTIYDYRA FIETSHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG 

       310        320        330        340        350        360 
PHAAYFATKE EYKRQVPGRI VGVSKDVHGK TALRLALQTR EQHIRREKAT SNICTAQVLL 

       370        380        390        400        410        420 
AVMASMYAVY HGPEGLKQIA ERIHHLTLVL GVWLQRLGYT ITSQSFFDTL QIKLGEKPLQ 

       430        440        450        460        470        480 
EILEAAEAYR INLRIVDTST VGISLDETTT LEDVKDICRI FAGTDELPFV LNVQEFDWII 

       490        500        510        520        530        540 
QQSSLKDEPF SRQSSYLTHP VFNRYHSETE LLRYLHRLET KDLSLTTSMI PLGSCTMKLN 

       550        560        570        580        590        600 
ATSEMIPVTW EEFGRIHPFA PLTQTRGYQI LFQQLEAWLG EITGFAGVSL QPNAGSQGEY 

       610        620        630        640        650        660 
TGLLVIRQYH QSRGETHRNV CLIPNSAHGT NPASAVMCGM KVVAVACDAG GNIDIDDLKA 

       670        680        690        700        710        720 
KAEKHSHELA ALMVTYPSTH GVFEAGIQEI CAVIHSHGGQ VYMDGANMNA QVGICRPGDI 

       730        740        750        760        770        780 
GADVCHLNLH KTFCIPHGGG GPGMGPIGVA SHLVPFLPGH PVLESGKNPQ NIGAVAAAPW 

       790        800        810        820        830        840 
GSASILVISW MYIVMMGADG LTQATKVAIL NANYIAKKLA AYYPVLYKGQ NGLVAHECIL 

       850        860        870        880        890        900 
DLRALKKSAN IEIDDIAKRL IDYGFHAPTV SWPVAGTIMV EPTESESQAE LDRFCEALIA 

       910        920        930        940        950        960 
IRQEIADIEA GKVDIQDNSL KNAPHTVESL IVGEWPHPYS REQAAYPAPW TREHKFWPSV 

       970        980 
GRIDAAFGDR NFVCSCLPMD AYN 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB76306.1.
PIRAG2381.
RefSeqNP_488647.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YNF9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.all4607.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB76306; BAB76306; BAB76306.
GeneID1108208.
KEGGana:all4607.
PATRIC22779832. VBINosSp37423_5362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_NOSS1
AccessionPrimary (citable) accession number: Q8YNF9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families