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Q8YNF9

- GCSP_NOSS1

UniProt

Q8YNF9 - GCSP_NOSS1

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, all4607
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:all4607
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 983983Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei731 – 7311N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi103690.all4607.

Structurei

3D structure databases

ProteinModelPortaliQ8YNF9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFHQYRSE.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YNF9-1 [UniParc]FASTAAdd to Basket

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MVSYASIPQS SDEAHSTVGA SLQLDERKQD LNNFIQRHIG PSSADIQQML    50
DVLGFSSLDD LIEKTVPSAI RLHEQLQLPE AQTEYAALAK LKQIASKNQV 100
FRSYIGMGYY DTITPSVIGR NILENPGWYT AYTPYQPEIA QGRLEALLNF 150
QTMIIDLTGL EIANASLLDE ATAAAEAMSM SYGVSKNKAN AYFVSHDCHP 200
QIIDVLQTRA KPLGIEIIIG DHQTFDFDKP IFGAVLQYPA SDGTIYDYRA 250
FIETSHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG 300
PHAAYFATKE EYKRQVPGRI VGVSKDVHGK TALRLALQTR EQHIRREKAT 350
SNICTAQVLL AVMASMYAVY HGPEGLKQIA ERIHHLTLVL GVWLQRLGYT 400
ITSQSFFDTL QIKLGEKPLQ EILEAAEAYR INLRIVDTST VGISLDETTT 450
LEDVKDICRI FAGTDELPFV LNVQEFDWII QQSSLKDEPF SRQSSYLTHP 500
VFNRYHSETE LLRYLHRLET KDLSLTTSMI PLGSCTMKLN ATSEMIPVTW 550
EEFGRIHPFA PLTQTRGYQI LFQQLEAWLG EITGFAGVSL QPNAGSQGEY 600
TGLLVIRQYH QSRGETHRNV CLIPNSAHGT NPASAVMCGM KVVAVACDAG 650
GNIDIDDLKA KAEKHSHELA ALMVTYPSTH GVFEAGIQEI CAVIHSHGGQ 700
VYMDGANMNA QVGICRPGDI GADVCHLNLH KTFCIPHGGG GPGMGPIGVA 750
SHLVPFLPGH PVLESGKNPQ NIGAVAAAPW GSASILVISW MYIVMMGADG 800
LTQATKVAIL NANYIAKKLA AYYPVLYKGQ NGLVAHECIL DLRALKKSAN 850
IEIDDIAKRL IDYGFHAPTV SWPVAGTIMV EPTESESQAE LDRFCEALIA 900
IRQEIADIEA GKVDIQDNSL KNAPHTVESL IVGEWPHPYS REQAAYPAPW 950
TREHKFWPSV GRIDAAFGDR NFVCSCLPMD AYN 983
Length:983
Mass (Da):107,753
Last modified:March 1, 2002 - v1
Checksum:i3255D178ED6CC6F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB76306.1.
PIRiAG2381.
RefSeqiNP_488647.1. NC_003272.1.
WP_010998738.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76306; BAB76306; BAB76306.
GeneIDi1108208.
KEGGiana:all4607.
PATRICi22779832. VBINosSp37423_5362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB76306.1 .
PIRi AG2381.
RefSeqi NP_488647.1. NC_003272.1.
WP_010998738.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YNF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all4607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76306 ; BAB76306 ; BAB76306 .
GeneIDi 1108208.
KEGGi ana:all4607.
PATRICi 22779832. VBINosSp37423_5362.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FHQYRSE.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiGCSP_NOSS1
AccessioniPrimary (citable) accession number: Q8YNF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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