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Q8YNF9

- GCSP_NOSS1

UniProt

Q8YNF9 - GCSP_NOSS1

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:all4607
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 983983Glycine dehydrogenase (decarboxylating)PRO_0000166902Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei731 – 7311N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi103690.all4607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YNF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFHQYRSE.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YNF9-1 [UniParc]FASTAAdd to Basket

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    MVSYASIPQS SDEAHSTVGA SLQLDERKQD LNNFIQRHIG PSSADIQQML    50
    DVLGFSSLDD LIEKTVPSAI RLHEQLQLPE AQTEYAALAK LKQIASKNQV 100
    FRSYIGMGYY DTITPSVIGR NILENPGWYT AYTPYQPEIA QGRLEALLNF 150
    QTMIIDLTGL EIANASLLDE ATAAAEAMSM SYGVSKNKAN AYFVSHDCHP 200
    QIIDVLQTRA KPLGIEIIIG DHQTFDFDKP IFGAVLQYPA SDGTIYDYRA 250
    FIETSHAQGA LVTVAADPLS LTLLTPPGEF GADIAVGSTQ RFGIPLGFGG 300
    PHAAYFATKE EYKRQVPGRI VGVSKDVHGK TALRLALQTR EQHIRREKAT 350
    SNICTAQVLL AVMASMYAVY HGPEGLKQIA ERIHHLTLVL GVWLQRLGYT 400
    ITSQSFFDTL QIKLGEKPLQ EILEAAEAYR INLRIVDTST VGISLDETTT 450
    LEDVKDICRI FAGTDELPFV LNVQEFDWII QQSSLKDEPF SRQSSYLTHP 500
    VFNRYHSETE LLRYLHRLET KDLSLTTSMI PLGSCTMKLN ATSEMIPVTW 550
    EEFGRIHPFA PLTQTRGYQI LFQQLEAWLG EITGFAGVSL QPNAGSQGEY 600
    TGLLVIRQYH QSRGETHRNV CLIPNSAHGT NPASAVMCGM KVVAVACDAG 650
    GNIDIDDLKA KAEKHSHELA ALMVTYPSTH GVFEAGIQEI CAVIHSHGGQ 700
    VYMDGANMNA QVGICRPGDI GADVCHLNLH KTFCIPHGGG GPGMGPIGVA 750
    SHLVPFLPGH PVLESGKNPQ NIGAVAAAPW GSASILVISW MYIVMMGADG 800
    LTQATKVAIL NANYIAKKLA AYYPVLYKGQ NGLVAHECIL DLRALKKSAN 850
    IEIDDIAKRL IDYGFHAPTV SWPVAGTIMV EPTESESQAE LDRFCEALIA 900
    IRQEIADIEA GKVDIQDNSL KNAPHTVESL IVGEWPHPYS REQAAYPAPW 950
    TREHKFWPSV GRIDAAFGDR NFVCSCLPMD AYN 983
    Length:983
    Mass (Da):107,753
    Last modified:March 1, 2002 - v1
    Checksum:i3255D178ED6CC6F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB76306.1.
    PIRiAG2381.
    RefSeqiNP_488647.1. NC_003272.1.
    WP_010998738.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB76306; BAB76306; BAB76306.
    GeneIDi1108208.
    KEGGiana:all4607.
    PATRICi22779832. VBINosSp37423_5362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB76306.1 .
    PIRi AG2381.
    RefSeqi NP_488647.1. NC_003272.1.
    WP_010998738.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YNF9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.all4607.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB76306 ; BAB76306 ; BAB76306 .
    GeneIDi 1108208.
    KEGGi ana:all4607.
    PATRICi 22779832. VBINosSp37423_5362.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FHQYRSE.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiGCSP_NOSS1
    AccessioniPrimary (citable) accession number: Q8YNF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3