Reviewed, UniProtKB/Swiss-Prot Q8YN49 (GCH12_ANASP)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1 2
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I 2
      Short name=GTP-CH-I 2

Gene names

Name:	folE2
Ordered Locus Names:	all4721

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	GTP cyclohydrolase 1 2 HAMAP MF_00223		PRO_0000119380

Sequences

	Sequence		Length	Mass (Da)
	Q8YN49-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: B74CFF1DAFBD5BA3	FASTA	216	23,942
	10 20 30 40 50 60 MTLSIRPDTV SAAQMVSSLS TQQTPTVTEA EMVQAVRTLL IGLGENPDRE GLLDTPKRVV 70 80 90 100 110 120 KALQFLTKGY NESLDELLNG AVFTEDANEM VLIRDIDIFS SCEHHILPII GRAHVAYIPN 130 140 150 160 170 180 GKVIGLSKIA RVCEMYARRL QVQERLTLQI ADALQGLLKP QGVAVVIEAT HMCMVMRGVQ 190 200 210 KPGSWTVTSA MRGVFAEDAR TREEFMNLVR HNANFH

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB76420.1.
PIR	AI2395.
RefSeq	NP_488761.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS8 based on UniProtKB P22288.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YN49.
Genome annotation databases
GeneID	1108322.
GenomeReviews	Gene locus all4721 in contig BA000019_GR.
KEGG	ana:all4721.
NMPDR	fig|103690.1.peg.5028.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YN49.
OMA	ILPIIGR.
Enzyme and pathway databases
BioCyc	NSP103690:ALL4721-MON.
Family and domain databases
HAMAP	MF_00223. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
ProDom	PD003330. GTP_cyclohydroI. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH12_ANASP

Accession

Primary (citable) accession number: Q8YN49

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)