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Q8YN49

- GCH12_NOSS1

UniProt

Q8YN49 - GCH12_NOSS1

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Protein

GTP cyclohydrolase 1 2

Gene

folE2

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 2 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I 2
Short name:
GTP-CH-I 2
Gene namesi
Name:folE2
Ordered Locus Names:all4721
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216GTP cyclohydrolase 1 2PRO_0000119380Add
BLAST

Interactioni

Subunit structurei

Homopolymer.By similarity

Protein-protein interaction databases

STRINGi103690.all4721.

Structurei

3D structure databases

ProteinModelPortaliQ8YN49.
SMRiQ8YN49. Positions 32-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiTSLPFAM.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YN49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLSIRPDTV SAAQMVSSLS TQQTPTVTEA EMVQAVRTLL IGLGENPDRE
60 70 80 90 100
GLLDTPKRVV KALQFLTKGY NESLDELLNG AVFTEDANEM VLIRDIDIFS
110 120 130 140 150
SCEHHILPII GRAHVAYIPN GKVIGLSKIA RVCEMYARRL QVQERLTLQI
160 170 180 190 200
ADALQGLLKP QGVAVVIEAT HMCMVMRGVQ KPGSWTVTSA MRGVFAEDAR
210
TREEFMNLVR HNANFH
Length:216
Mass (Da):23,942
Last modified:March 1, 2002 - v1
Checksum:iB74CFF1DAFBD5BA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB76420.1.
PIRiAI2395.
RefSeqiNP_488761.1. NC_003272.1.
WP_010998852.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76420; BAB76420; BAB76420.
GeneIDi1108322.
KEGGiana:all4721.
PATRICi22780078. VBINosSp37423_5482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB76420.1 .
PIRi AI2395.
RefSeqi NP_488761.1. NC_003272.1.
WP_010998852.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YN49.
SMRi Q8YN49. Positions 32-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all4721.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76420 ; BAB76420 ; BAB76420 .
GeneIDi 1108322.
KEGGi ana:all4721.
PATRICi 22780078. VBINosSp37423_5482.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi TSLPFAM.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiGCH12_NOSS1
AccessioniPrimary (citable) accession number: Q8YN49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3