Reviewed, UniProtKB/Swiss-Prot Q8YMM6 (OTC_ANASP)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	alr4907

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112873
Regions
	Region	51 – 55	5	Carbamoyl phosphate binding By similarity
	Region	262 – 265	4	Ornithine binding By similarity
Sites
	Binding site	102	1	Carbamoyl phosphate By similarity
	Binding site	129	1	Carbamoyl phosphate By similarity
	Site	31	1	Important for structural integrity By similarity
	Site	142	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YMM6-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: D2E58BA1C6D08983	FASTA	306	33,401
	10 20 30 40 50 60 MAALLGRDLL SLADLTPTEL QELLQLATQL KSQQLKLRCN KVLGLLFSKA STRTRVSFTV 70 80 90 100 110 120 AMYQLGGQVI DLNPNVTQVS RGEPVQDTAR VLERYLDVLA IRTFEQQELA TFAEYAKIPV 130 140 150 160 170 180 INALTDLEHP CQILADLLTV QECFDSISGL TLTYVGDGNN VANSLMLGCA LAGMNVRIAT 190 200 210 220 230 240 PSGYEPNPQV VAQAQAIADG KTEILLTNDP DLATKGASVL YTDVWASMGQ EAEADDRFPI 250 260 270 280 290 300 FQPYQISEQL LSLAEPNAIV LHCLPAHRGE EITEEVIEGS QSRVWQQAEN RLHVQKALLA SILGAE

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB76606.1.
PIR	AC2419.
RefSeq	NP_488947.1.
3D structure databases
HSSP	HSSP built from PDB template 1A1S based on UniProtKB Q51742.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YMM6.
Genome annotation databases
GeneID	1108508.
GenomeReviews	Gene locus alr4907 in contig BA000019_GR.
KEGG	ana:alr4907.
NMPDR	fig|103690.1.peg.5214.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YMM6.
OMA	YQLGGQV.
Enzyme and pathway databases
BioCyc	NSP103690:ALR4907-MON.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ANASP

Accession

Primary (citable) accession number: Q8YMM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)