ID   Q8YMH0_NOSS1            Unreviewed;      1155 AA.
AC   Q8YMH0;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   Name=cyaC {ECO:0000313|EMBL:BAB76662.1};
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690 {ECO:0000313|EMBL:BAB76662.1, ECO:0000313|Proteomes:UP000002483};
RN   [1] {ECO:0000313|EMBL:BAB76662.1, ECO:0000313|Proteomes:UP000002483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576
RC   {ECO:0000313|Proteomes:UP000002483};
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; BA000019; BAB76662.1; -; Genomic_DNA.
DR   PIR; AC2426; AC2426.
DR   RefSeq; WP_010999089.1; NZ_RSCN01000018.1.
DR   AlphaFoldDB; Q8YMH0; -.
DR   STRING; 103690.gene:10497018; -.
DR   DNASU; 1108564; -.
DR   KEGG; ana:all4963; -.
DR   eggNOG; COG0745; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2203; Bacteria.
DR   eggNOG; COG2205; Bacteria.
DR   eggNOG; COG3437; Bacteria.
DR   OrthoDB; 414909at2; -.
DR   BRENDA; 4.6.1.1; 8113.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd17569; REC_HupR-like; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.450.40; -; 2.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR   PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR   Pfam; PF01590; GAF; 2.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00072; Response_reg; 2.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 2.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF52172; CheY-like; 2.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW   ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000002483};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          10..125
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          521..735
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   DOMAIN          798..914
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          964..1104
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   MOD_RES         59
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT   MOD_RES         847
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   1155 AA;  128784 MW;  C40C50B8DAA35961 CRC64;
     MKSPVNSKPK ILVVDDEPDN LDLLYRTFYR DYKVLRAISG PAALDLLAQE GEIAVIISDQ
     RMPIMSGTEF LSLTATQYPD IIRIILTGYT DVEDLVEAIN AGKVFKYVTK PWEAEELKAV
     VRQALDTHNV LKARTRELTR TLRQESLLNT VTNTIRSALD YRQILQAIVD TVGHMLEVDV
     CLLRSFQDGQ LVDEGFVYQK DSPAAVEKTI HDSAPLTILA DTVWETREVQ IIHDVAGDER
     IHGDSPELQH RNDAFAAADI RSSLVVPLIC QQELMAVLAL HQCSQARVWG EEEVQLVLMV
     ADQAALALSQ AYAYEQVRAL AKRESLINTI TTAIRSSLNP EDIFAAITQK LGQALQVDGC
     VLSLWTEEDE FVKCVGLYDS SRHSEDSLDN HRLITQELPE SQAPILENPI LQEILKTHEP
     VIITDMNHSD WETKRFDLHL KMPARSLMVV PLLADGKCIG SITLREGKRA RQWLSADIEL
     AKAVAAQAAI AVQQSHLYQK TREQAERLLQ LDKQKTEFFQ NISHEFRTPI TLIQGPLESA
     VGTGEGLSYA QSAIALRNSR RLLRLVNQLL DLQRLDAGRM QPSFRPCDLV DFVSQIVESF
     RPYCEKKALH LTTELDECPT VYIDMEKFDK VVYNLLSNAM KFTPEGGTIS VKLQSQGHHC
     ILQVQDTGIG IVKEQIPHLF ERFRQAEGSE NRSYEGSGLG LALVKELVEL HGGRVTVESV
     YGKGTTFTLW LVIGNAHLPL QQVSDTPVEL TTSRASVELA DLELVEPTLE NIDIETINPL
     PISETQHTAN STQQSTHSIL VVDDNPDLRT YVSDILRRSG YQVYTARNGY EGFSKVQELT
     PNLIVTDLMM PLVTGLEMIR MVRNDEKVKG TPIILLTAKV DEETRIESTE HGADAYLAKP
     FNDRELLAEV RNLLALKENE KRVLELNTYL TESVLKRFLP PALVSKAAAG SLSLDLRPEP
     RLITVLFSDI VGFTQLANTL RSRRVAELLN EYLEFMTKAV FDNGGTVDKF MGDAILALYG
     APEELTPNEQ VRRAVNTARA MHSSLAQLNQ RWRNQGIFDT HDYGGVQFRC GIHQGTAVVG
     MFGSAERADY TAIGPSVNIA ARLQSAAVPG TILVSAAVAD YLQDEEITKG SPLKLKGIDE
     TVLTFAVKSE LMVNR
//