Reviewed, UniProtKB/Swiss-Prot Q8YMG7 (HIS82_ANASP)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	all4966

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153294
Amino acid modifications
	Modified residue	236	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YMG7-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 436A87712C768DEA	FASTA	384	42,118
	10 20 30 40 50 60 MLPFIRSDLA QFNAYKPHPS SDTASAVPPQ LDRLDTNESP YDLPPELKQK LAWTFQQVIE 70 80 90 100 110 120 SNRYPDGGHE TLKSAIAEYV NESANISSLR FTAANISVGN GSDELIRSLL IATCLSGEGS 130 140 150 160 170 180 ILVANPTFSM YGILAQTLGI PVVSVSRNPD NFAIDLTAAQ SAIEQTLNPP IRVVFVVHPN 190 200 210 220 230 240 SPTANPLTAN ELRWLKSLSE RILVVVDEAY FEFSQNTLVS ELAQRPNWII LRTFSKAFRL 250 260 270 280 290 300 AAMRVGYCVA HPEAIAILEK VRLPYNLPSF SIASALVALQ NRAILLESIP QTLDERTKLI 310 320 330 340 350 360 NAFSQHPALA VAESAANFIF LRLKADSDNS SDTTLLNLHQ QLKNSGTLVR QISGGLRITI 370 380 GTPEENIRTL NHIQTALIKP ELVG

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB76665.1.
PIR	AF2426.
RefSeq	NP_489006.1.
3D structure databases
SMR	Q8YMG7. Positions 4-373.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YMG7.
Genome annotation databases
GeneID	1108567.
GenomeReviews	Gene locus all4966 in contig BA000019_GR.
KEGG	ana:all4966.
NMPDR	fig|103690.1.peg.5273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	DANECAY.
PhylomeDB	Q8YMG7.
Enzyme and pathway databases
BioCyc	NSP103690:ALL4966-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_ANASP

Accession

Primary (citable) accession number: Q8YMG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2002
Last modified:	January 19, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)