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Protein

Histidinol-phosphate aminotransferase 2

Gene

hisC2

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase 2 (hisD2), Histidinol dehydrogenase 1 (hisD1)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 2 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 2
Gene namesi
Name:hisC2
Ordered Locus Names:all4966
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532941 – 384Histidinol-phosphate aminotransferase 2Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi103690.all4966

Structurei

3D structure databases

ProteinModelPortaliQ8YMG7
SMRiQ8YMG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiTYGMYKV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YMG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFIRSDLA QFNAYKPHPS SDTASAVPPQ LDRLDTNESP YDLPPELKQK
60 70 80 90 100
LAWTFQQVIE SNRYPDGGHE TLKSAIAEYV NESANISSLR FTAANISVGN
110 120 130 140 150
GSDELIRSLL IATCLSGEGS ILVANPTFSM YGILAQTLGI PVVSVSRNPD
160 170 180 190 200
NFAIDLTAAQ SAIEQTLNPP IRVVFVVHPN SPTANPLTAN ELRWLKSLSE
210 220 230 240 250
RILVVVDEAY FEFSQNTLVS ELAQRPNWII LRTFSKAFRL AAMRVGYCVA
260 270 280 290 300
HPEAIAILEK VRLPYNLPSF SIASALVALQ NRAILLESIP QTLDERTKLI
310 320 330 340 350
NAFSQHPALA VAESAANFIF LRLKADSDNS SDTTLLNLHQ QLKNSGTLVR
360 370 380
QISGGLRITI GTPEENIRTL NHIQTALIKP ELVG
Length:384
Mass (Da):42,118
Last modified:March 1, 2002 - v1
Checksum:i436A87712C768DEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA Translation: BAB76665.1
PIRiAF2426
RefSeqiWP_010999092.1, NC_003272.1

Genome annotation databases

EnsemblBacteriaiBAB76665; BAB76665; BAB76665
KEGGiana:all4966

Similar proteinsi

Entry informationi

Entry nameiHIS82_NOSS1
AccessioniPrimary (citable) accession number: Q8YMG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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