Q8YMB5 (AROA_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	all5019

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088216

Sequences

	Sequence		Length	Mass (Da)
	Q8YMB5 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 10C58E19361E9C45	FASTA	425	46,532
	10 20 30 40 50 60 MDTIAIPALN RPVDATVEIP GSKSITNRAL LVAALAQGDS TLENALFSED SEYFAKCVEQ 70 80 90 100 110 120 LGIPITLHPH LAQIQVSGKG GDIPAKQADL FVGLAGTAAR FITALVALGN GEYRLDGVPR 130 140 150 160 170 180 MRERPMGDLV TVLQNSGITI NFEGNSGFMP YTIYGQQFAG GHFRLKANQT SQQLSALLMI 190 200 210 220 230 240 APYAQQDTTI EVEGTLVSQS YVKMTCRLMA DFGVDVTQTD DNQFHIKAGQ RYQARHYTIE 250 260 270 280 290 300 PDASNASYFF AAAAVTGGRV RVNHLTKQSC QGDILWLNVL EQMGCQVIEG ADYTEVIGPE 310 320 330 340 350 360 QLQGIDIDMN DMSDLVQTLG AIAPYASSPV IIRNVEHIRY KETERIRAVV TELRRLGVKV 370 380 390 400 410 420 EEFADGMKIE PTPITPAAIE TYHDHRMAMA FAVTGLKTPG IVIQDPGCTA KTFPDYFTRF FKMID

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB76718.1.
PIR	AC2433.
RefSeq	NP_489059.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YMB5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YMB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1108623.
GenomeReviews	Gene locus all5019 in contig BA000019_GR.
KEGG	ana:all5019.
NMPDR	fig|103690.1.peg.5326.
PATRIC	22780723. VBINosSp37423_5801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	Q8YMB5.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	NSP103690:ALL5019-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_NOSS1

Accession

Primary (citable) accession number: Q8YMB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program