Q8YM77 (NADD_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable nicotinate-nucleotide adenylyltransferase
EC=2.7.7.18

Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase

Gene names

Name:	nadD
Ordered Locus Names:	all5063

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244
Catalytic activity	ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244
Sequence similarities	Belongs to the NadD family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244		PRO_0000181377

Sequences

	Sequence		Length	Mass (Da)
	Q8YM77 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: BBEFABE0EF995510	FASTA	208	23,745
	10 20 30 40 50 60 MQHLAVFGGT FDPIHWGHLL IAEAALQQIP IEKVIWVPSL NPPHKKASAF RHRLAMLQLA 70 80 90 100 110 120 TQDNPAFTVS SVEKNRSGVS YAINTLTDLS VCFPNTHWYW IVGLDTFQTL PRWYRGQELA 130 140 150 160 170 180 PMCDWLIAPR LVGGENIAQS ELICKQVKQQ LRKQSDTIHW HLLHIPLVGV SSSLIRKLYR 190 200 IGKSIRYLVP EDVRSYIAAH KLYSEDSE

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB76762.1.
PIR	AG2438.
RefSeq	NP_489103.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YM77.
ModBase	Search...
Protein-protein interaction databases
STRING	103690.all5063.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB76762; BAB76762; BAB76762.
GeneID	1108667.
KEGG	ana:all5063.
PATRIC	22780817. VBINosSp37423_5848.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1057.
HOGENOM	HOG000262780.
KO	K00969.
OMA	IPPHKNT.
ProtClustDB	CLSK286670.
Enzyme and pathway databases
UniPathway	UPA00253; UER00332.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00244. NaMN_adenylyltr.
InterPro	IPR004821. Cyt_trans-like. IPR005248. NAMN_adtrnsfrase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR12039. PTHR12039. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADD_NOSS1

Accession

Primary (citable) accession number: Q8YM77

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program