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Reviewed, UniProtKB/Swiss-Prot Q8YM41 (PYRE_ANASP)

Last modified February 9, 2010. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: alr5099
OrganismAnabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110664

Regions

Region141 – 14995-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site11415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site11515-phosphoribose 1-diphosphate By similarity
Binding site11815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site12015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1451Orotate By similarity
Binding site1731Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YM41-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 958628E4258E250F

FASTA20622,199
        10         20         30         40         50         60 
MTYSTESLAQ SDIWPATADV STLRRKLLDL LCQLAYKEGD FVLSSGQPSS YYINGKQVTL 

        70         80         90        100        110        120 
HPQGALAIGR ILLSLLPSDT QAVAGLTLGA DPIVTAVSVV SAYENRPIPA LIIRKEAKGH 

       130        140        150        160        170        180 
GTKAYIEGPN LPEGAKVVVL EDVVTTGQSA MKAVDRLRAA GYVVDEVISL VDRQQGGAEF 

       190        200 
YQSVGLKFEA VFTIMDLQQR YQELGN 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB76798.1.
PIRAC2443.
RefSeqNP_489139.1.

3D structure databases

SMRQ8YM41. Positions 22-202.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8YM41.

Genome annotation databases

GeneID1108703.
GenomeReviewsGene locus alr5099 in contig BA000019_GR.
KEGGana:alr5099.
NMPDRfig|103690.1.peg.5406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMANCKPVSL.
PhylomeDBQ8YM41.

Enzyme and pathway databases

BioCycNSP103690:ALR5099-MONOMER.

Family and domain databases

HAMAPMF_01208_B. PyrE_B.
[Tree]
InterProIPR004467. Or_phspho_trans.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. pyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_ANASP
AccessionPrimary (citable) accession number: Q8YM41
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents