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Q8YLL1 (GCH11_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I 1
Short name=GTP-CH-I 1
Gene names
Name:folE1
Ordered Locus Names:alr5287
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235GTP cyclohydrolase 1 1 HAMAP-Rule MF_00223
PRO_0000119379

Sequences

Sequence LengthMass (Da)Tools
Q8YLL1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 64044971731BE2AD

FASTA23526,524
        10         20         30         40         50         60 
MTIASSNGSN RAQSPLITDL AEAINTRPDR NTHNGREPEL HQPSEEDMES MMGAVRSILV 

        70         80         90        100        110        120 
GVGEDPEREG LLKTPKRVAE AMRFLTSGYN QSLEELLNGA VFDEGHNEMV LVRDINFFSL 

       130        140        150        160        170        180 
CEHHMLPFMG RAHVAYIPNQ KVVGLSKLAR IVEMYSRRLQ VQERLTRQIA EAVQTILEPQ 

       190        200        210        220        230 
GVAVVMEASH MCMVMRGVQK PGSWTVTSAM LGVFQEEQKT REEFFNLIRH QPAFF 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000019 Genomic DNA. Translation: BAB76986.1.
PIRAG2466.
RefSeqNP_489327.1. NC_003272.1.

3D structure databases

ProteinModelPortalQ8YLL1.
SMRQ8YLL1. Positions 38-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.alr5287.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB76986; BAB76986; BAB76986.
GeneID1108891.
KEGGana:alr5287.
PATRIC22781289. VBINosSp37423_6082.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAMEENEMD.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH11_NOSS1
AccessionPrimary (citable) accession number: Q8YLL1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways