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Q8YLL1

- GCH11_NOSS1

UniProt

Q8YLL1 - GCH11_NOSS1

Protein

GTP cyclohydrolase 1 1

Gene

folE1

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1 1 (EC:3.5.4.16)
    Alternative name(s):
    GTP cyclohydrolase I 1
    Short name:
    GTP-CH-I 1
    Gene namesi
    Name:folE1
    Ordered Locus Names:alr5287
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235GTP cyclohydrolase 1 1PRO_0000119379Add
    BLAST

    Interactioni

    Subunit structurei

    Homopolymer.By similarity

    Protein-protein interaction databases

    STRINGi103690.alr5287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YLL1.
    SMRiQ8YLL1. Positions 38-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiMEENEMD.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YLL1-1 [UniParc]FASTAAdd to Basket

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    MTIASSNGSN RAQSPLITDL AEAINTRPDR NTHNGREPEL HQPSEEDMES    50
    MMGAVRSILV GVGEDPEREG LLKTPKRVAE AMRFLTSGYN QSLEELLNGA 100
    VFDEGHNEMV LVRDINFFSL CEHHMLPFMG RAHVAYIPNQ KVVGLSKLAR 150
    IVEMYSRRLQ VQERLTRQIA EAVQTILEPQ GVAVVMEASH MCMVMRGVQK 200
    PGSWTVTSAM LGVFQEEQKT REEFFNLIRH QPAFF 235
    Length:235
    Mass (Da):26,524
    Last modified:March 1, 2002 - v1
    Checksum:i64044971731BE2AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB76986.1.
    PIRiAG2466.
    RefSeqiNP_489327.1. NC_003272.1.
    WP_010999411.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB76986; BAB76986; BAB76986.
    GeneIDi1108891.
    KEGGiana:alr5287.
    PATRICi22781289. VBINosSp37423_6082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB76986.1 .
    PIRi AG2466.
    RefSeqi NP_489327.1. NC_003272.1.
    WP_010999411.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8YLL1.
    SMRi Q8YLL1. Positions 38-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr5287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB76986 ; BAB76986 ; BAB76986 .
    GeneIDi 1108891.
    KEGGi ana:alr5287.
    PATRICi 22781289. VBINosSp37423_6082.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi MEENEMD.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiGCH11_NOSS1
    AccessioniPrimary (citable) accession number: Q8YLL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3