Reviewed, UniProtKB/Swiss-Prot Q8YLL1 (GCH11_ANASP)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I 1
      Short name=GTP-CH-I 1

Gene names

Name:	folE1
Ordered Locus Names:	alr5287

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	GTP cyclohydrolase 1 1 HAMAP MF_00223		PRO_0000119379

Sequences

	Sequence		Length	Mass (Da)
	Q8YLL1-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 64044971731BE2AD	FASTA	235	26,524
	10 20 30 40 50 60 MTIASSNGSN RAQSPLITDL AEAINTRPDR NTHNGREPEL HQPSEEDMES MMGAVRSILV 70 80 90 100 110 120 GVGEDPEREG LLKTPKRVAE AMRFLTSGYN QSLEELLNGA VFDEGHNEMV LVRDINFFSL 130 140 150 160 170 180 CEHHMLPFMG RAHVAYIPNQ KVVGLSKLAR IVEMYSRRLQ VQERLTRQIA EAVQTILEPQ 190 200 210 220 230 GVAVVMEASH MCMVMRGVQK PGSWTVTSAM LGVFQEEQKT REEFFNLIRH QPAFF

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB76986.1.
PIR	AG2466.
RefSeq	NP_489327.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS8 based on UniProtKB P22288.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YLL1.
Genome annotation databases
GeneID	1108891.
GenomeReviews	Gene locus alr5287 in contig BA000019_GR.
KEGG	ana:alr5287.
NMPDR	fig|103690.1.peg.5594.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YLL1.
OMA	RITSTIA.
Enzyme and pathway databases
BioCyc	NSP103690:ALR5287-MON.
Family and domain databases
HAMAP	MF_00223. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
ProDom	PD003330. GTP_cyclohydroI. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH11_ANASP

Accession

Primary (citable) accession number: Q8YLL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)