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Q8YLL1

- GCH11_NOSS1

UniProt

Q8YLL1 - GCH11_NOSS1

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Protein

GTP cyclohydrolase 1 1

Gene

folE1

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I 1
Short name:
GTP-CH-I 1
Gene namesi
Name:folE1
Ordered Locus Names:alr5287
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235GTP cyclohydrolase 1 1PRO_0000119379Add
BLAST

Interactioni

Subunit structurei

Homopolymer.By similarity

Protein-protein interaction databases

STRINGi103690.alr5287.

Structurei

3D structure databases

ProteinModelPortaliQ8YLL1.
SMRiQ8YLL1. Positions 38-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiMEENEMD.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YLL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIASSNGSN RAQSPLITDL AEAINTRPDR NTHNGREPEL HQPSEEDMES
60 70 80 90 100
MMGAVRSILV GVGEDPEREG LLKTPKRVAE AMRFLTSGYN QSLEELLNGA
110 120 130 140 150
VFDEGHNEMV LVRDINFFSL CEHHMLPFMG RAHVAYIPNQ KVVGLSKLAR
160 170 180 190 200
IVEMYSRRLQ VQERLTRQIA EAVQTILEPQ GVAVVMEASH MCMVMRGVQK
210 220 230
PGSWTVTSAM LGVFQEEQKT REEFFNLIRH QPAFF
Length:235
Mass (Da):26,524
Last modified:March 1, 2002 - v1
Checksum:i64044971731BE2AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB76986.1.
PIRiAG2466.
RefSeqiNP_489327.1. NC_003272.1.
WP_010999411.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76986; BAB76986; BAB76986.
GeneIDi1108891.
KEGGiana:alr5287.
PATRICi22781289. VBINosSp37423_6082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB76986.1 .
PIRi AG2466.
RefSeqi NP_489327.1. NC_003272.1.
WP_010999411.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YLL1.
SMRi Q8YLL1. Positions 38-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr5287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76986 ; BAB76986 ; BAB76986 .
GeneIDi 1108891.
KEGGi ana:alr5287.
PATRICi 22781289. VBINosSp37423_6082.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi MEENEMD.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiGCH11_NOSS1
AccessioniPrimary (citable) accession number: Q8YLL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3